Results 111 to 120 of about 89,658 (280)
eLife, 2019 Neurons throughout the mammalian brain possess non-motile cilia, organelles with varied functions in sensory physiology and cellular signaling. Yet, the roles of cilia in these neurons are poorly understood. To shed light into their functions, we studied
Catrina M Loucks +13 more
doaj +1 more source
Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells
Advanced Science, EarlyView.ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen +11 more
wiley +1 more source
Sensory reception is an attribute of both primary cilia and motile cilia [PDF]
Journal of Cell Science, 2010 A recent cluster of papers has shown that motile cilia in the respiratory and reproductive tracts of humans and other mammals can exhibit sensory functions, a function previously attributed primarily to non-motile primary cilia. This leads to a new paradigm that all cilia and flagella (both motile and primary) can mediate sensory functions.
openaire +2 more sources
Robust estimation of the motile cilia beating frequency [PDF]
Medical & Biological Engineering & Computing, 2015 The estimation of the cilia beating frequency (CBF) is of great interest in understanding how the CBF modulates liquid fluxes and how it is controlled by the ciliated cell intra- and/or extracellular medium composition in physiological processes. Motion artifacts and camera defaults may hinder the computation of the frequency variations during long ...
Meste, Olivier +2 more
openaire +2 more sources
Omnivory by the Small Cosmopolitan Hydromedusa Aglaura Hemistoma [PDF]
, 2005 We investigated the feeding of the small hydromedusa, Aglaura hemistoma (bell diameter \u3c 4 mm), to determine if it occupies a trophic position similar to that of large medusae.
Colin, Sean +3 more
core +2 more sources
Arl3 regulates ODA16-mediated intraflagellar transport in motile cilia biogenesis [PDF]
, 2023 Yameng Huang +5 more
openalex +1 more source
Primary ciliary dyskinesia (PCD): A genetic disorder of motile cilia
Translational Science of Rare Diseases, 2019 Primary ciliary dyskinesia (PCD) is a genetic disorder of motile cilia. Clinical features include chronic oto-sino-pulmonary disease, laterality defects, and male fertility reflecting impaired function of respiratory cilia in the upper and lower ...
M. Leigh +5 more
semanticscholar +1 more source
A Structural Basis for How Motile Cilia Beat [PDF]
BioScience, 2014 The motile cilium is a mechanical wonder, a cellular nanomachine that produces a high-speed beat based on a cycle of bends that move along an axoneme made of 9+2 microtubules. The molecular motors, dyneins, power the ciliary beat. The dyneins are compacted into inner and outer dynein arms, whose activity is highly regulated to produce microtubule ...
Peter, Satir +2 more
openaire +2 more sources
Screw‐Based Pill for Intelligent Robotic Extraction of Viscous Fluids in Medical Applications
Advanced Intelligent Systems, EarlyView.Screw‐based pill for intelligent robotic extraction (S‐PIRE) is a magnetically actuated smart capsule with a motorized screw, 3‐axis sensor, and Bluetooth control for site‐specific and minimally invasive remote sampling of viscous fluids, overcoming passive diffusion limitations.
Prima Dewi Sinawang +6 more
wiley +1 more source
PLoS Genetics, 2023 An essential process during Danio rerio's left-right organizer (Kupffer's Vesicle, KV) formation is the formation of a motile cilium by developing KV cells which extends into the KV lumen. Beating of motile cilia within the KV lumen directs fluid flow to
Abrar A Aljiboury +10 more
doaj +1 more source