Mucociliary Wnt signaling promotes cilia biogenesis and beating
Nature Communications, 2023 Motile cilia are thought of as signaling-inert nanomotors. Here, the authors show that motile cilia transduce a Wnt-protein phosphatase 1 signal that regulates cilia biogenesis and ciliary beating in Xenopus embryos and in human airway epithelia.
Carina Seidl +5 more
doaj +1 more source
Rethinking the cilia hypothesis of hydrocephalus
Neurobiology of Disease, 2022 Dysfunction of motile cilia in ependymal cells has been proposed to be a pathogenic cause of cerebrospinal fluid (CSF) overaccumulation leading to ventricular expansion in hydrocephalus, primarily based on observations of enlarged ventricles in mouse ...
Phan Q. Duy +3 more
doaj +1 more source
Author Correction: Microridge-like structures anchor motile cilia [PDF]
Nat CommunTakayuki Yasunaga +13 more
openalex +2 more sources
Sperm defects in primary ciliary dyskinesia and related causes of male infertility [PDF]
, 2020 The core axoneme structure of both the motile cilium and sperm tail has the same ultrastructural 9 + 2 microtubular arrangement. Thus, it can be expected that genetic defects in motile cilia also have an effect on sperm tail formation.
Loebinger, Michael R. +4 more
core +2 more sources
Scientific Reports, 2021 Cilia are protrusions of the cell surface and composed of hundreds of proteins many of which are evolutionary and functionally well conserved. In cells assembling motile cilia the expression of numerous ciliary components is under the control of the ...
Anja Beckers +14 more
doaj +1 more source
TUBB4B is essential for the cytoskeletal architecture of cochlear supporting cells and motile cilia development [PDF]
Commun BiolUrikhan Sanzhaeva +10 more
openalex +2 more sources
Chloride channels regulate differentiation and barrier functions of the mammalian airway. [PDF]
, 2020 The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction ...
Caplan, Michael J +14 more
core +2 more sources
Motile cilia genetics and cell biology: big results from little mice [PDF]
Cell Mol Life Sci, 2020 Lance Lee, L. Ostrowski
semanticscholar +2 more sources
Purification and Immunostaining of Mouse Ependymal Ciliary Shafts
Bio-Protocol, 2022 Cilia and flagella are microtubule-based hair-like organelles protruding from the surface of most eukaryotic cells, and play essential roles in cell locomotion, left-right asymmetry, embryo development, and tissue homeostasis.
Kai Hao, Xueliang Zhu , Xiumin Yan
doaj +1 more source
Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry [PDF]
, 2016 The establishment of left–right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and ...
Betleja, Ewelina +8 more
core +2 more sources