Results 71 to 80 of about 89,658 (280)

DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia. [PDF]

PLoS Genetics, 2016
Heterotaxy, a birth defect involving left-right patterning defects, and primary ciliary dyskinesia (PCD), a sinopulmonary disease with dyskinetic/immotile cilia in the airway are seemingly disparate diseases.
You Li, Hisato Yagi, Ezenwa Obi Onuoha, Rama Rao Damerla, Richard Francis, Yoshiyuki Furutani, Muhammad Tariq, Stephen M King, Gregory Hendricks, Cheng Cui, Manush Saydmohammed, Dong Min Lee, Maliha Zahid, Iman Sami, Linda Leatherbury, Gregory J Pazour, Stephanie M Ware, Toshio Nakanishi, Elizabeth Goldmuntz, Michael Tsang, Cecilia W Lo   +20 more
doaj   +1 more source

Basal body stability and ciliogenesis requires the conserved component Poc1 [PDF]

, 2009
Centrioles are the foundation for centrosome and cilia formation. The biogenesis of centrioles is initiated by an assembly mechanism that first synthesizes the ninefold symmetrical cartwheel and subsequently leads to a stable cylindrical microtubule ...
Abal, Andersen, Avidor-Reiss, Azimzadeh, Badano, Bakowska, Balczon, Baron, Basmussen, Basto, Beisson, Berbari, Blachon, Bobinnec, Bobinnec, Broadhead, Brown, Bruns, Chad G. Pearson, Cheeseman, Culver, Dammermann, Dammermann, Daniel P.S. Osborn, Dupuis-Williams, Dutcher, Dutcher, Dutcher, Eddé, Eggenschwiler, Essner, Fry, Gaertig, Garreau de Loubresse, Gerdes, Graser, Gundersen, Hai, Hames, Hentschel, Hildebrandt, Hiraki, Jerka-Dziadosz, Kaczanowski, Keller, Keller, Kilburn, Kirkham, Kochanski, Le Clech, Leidel, Leidel, Leidel, Li, Liu, Mark Winey, Marshall, Marshall, Martinez-Campos, Matsuura, Million, Mottier-Pavie, Nakazawa, Nanney, Neuhauss, Orias, Paoletti, Pearson, Pearson, Pelletier, Peterkin, Philip L. Beales, Piperno, Rodrigues-Martins, Salisbury, Shang, Shang, Stemm-Wolf, Strnad, Thomas H. Giddings, Tobin, Tobin, Vladar, Westerfield, Wilkinson, Williams, Wloga, Woodland   +87 more
core   +2 more sources

ciliaFA : a research tool for automated, high-throughput measurement of ciliary beat frequency using freely available software [PDF]

, 2012
Background: Analysis of ciliary function for assessment of patients suspected of primary ciliary dyskinesia (PCD) and for research studies of respiratory and ependymal cilia requires assessment of both ciliary beat pattern and beat frequency.
C O’Callaghan, CL O’Callaghan, CM Smith, CW Wilson, EE Davis, G Mantovani, JH Sisson, JJ Ballenger, JR Kennedy, M Ryser, MA Chilvers, MA Chilvers, RA Hirst, RA Hirst, RA Hirst, S Dimova, TJ Mitchell, WA Stannard, WI Lee, WS Rasband   +19 more
core   +1 more source

Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies

Frontiers in Genetics, 2019
The motile cilium/flagellum is an ancient eukaryotic organelle. The molecular machinery of ciliary motility comprises a variety of cilium-specific dynein motor complexes along with other complexes that regulate their activity.
Petra zur Lage, Fay G. Newton, Andrew P. Jarman   +2 more
doaj   +1 more source

A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. [PDF]

, 2017
Control of organellar assembly and function is critical to eukaryotic homeostasis and survival. Gle1 is a highly conserved regulator of RNA-dependent DEAD-box ATPase proteins, with critical roles in both mRNA export and translation.
Akef, Abdalla, Jao, Li-En, Wente, Susan R   +2 more
core   +1 more source

Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish [PDF]

, 2010
Background: In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway.
Ingham, P.W., Kim, H.R., Richardson, J., van Eeden, F.   +3 more
core   +3 more sources

Ciliary Proteins: Filling the Gaps. Recent Advances in Deciphering the Protein Composition of Motile Ciliary Complexes

Cells, 2019
Cilia are highly evolutionarily conserved, microtubule-based cell protrusions present in eukaryotic organisms from protists to humans, with the exception of fungi and higher plants.
Anna Osinka, Martyna Poprzeczko, Magdalena M. Zielinska, Hanna Fabczak, Ewa Joachimiak, Dorota Wloga   +5 more
doaj   +1 more source

The Reissner fiber under tension in vivo shows dynamic interaction with ciliated cells contacting the cerebrospinal fluid

eLife, 2023
The Reissner fiber (RF) is an acellular thread positioned in the midline of the central canal that aggregates thanks to the beating of numerous cilia from ependymal radial glial cells (ERGs) generating flow in the central canal of the spinal cord.
Celine Bellegarda, Guillaume Zavard, Lionel Moisan, Françoise Brochard-Wyart, Jean-François Joanny, Ryan S Gray, Yasmine Cantaut-Belarif, Claire Wyart   +7 more
doaj   +1 more source

Mixing and transport by ciliary carpets: a numerical study [PDF]

, 2013
We use a 3D computational model to study the fluid transport and mixing due to the beating of an infinite array of cilia. In accord with recent experiments, we observe two distinct regions: a fluid transport region above the cilia and a fluid mixing ...
Ding, Yang, Kanso, Eva, McFall-Ngai, Margaret, Nawroth, Janna   +3 more
core   +3 more sources

Evolutionary origins of sensation in metazoans: functional evidence for a new sensory organ in sponges [PDF]

, 2014
Background: One of the hallmarks of multicellular organisms is the ability of their cells to trigger responses to the environment in a coordinated manner.
Farrar, Nathan, Leys, Sally P, Ludeman, Danielle A, Paps, Jordi, Riesgo, Ana   +4 more
core   +1 more source