Chloride channels regulate differentiation and barrier functions of the mammalian airway. [PDF]
The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction ...
Caplan, Michael J+14 more
core +1 more source
Exploring the role of fallopian ciliated cells in the pathogenesis of high-grade serous ovarian cancer [PDF]
High-grade serous epithelial ovarian cancer (HGSOC) is the fifth leading cause of cancer death in women and the first among gynecological malignancies. Despite an initial response to standard chemotherapy, most HGSOC patients relapse.
Baldassarre G+9 more
core +1 more source
Robust estimation of the motile cilia beating frequency [PDF]
The estimation of the cilia beating frequency (CBF) is of great interest in understanding how the CBF modulates liquid fluxes and how it is controlled by the ciliated cell intra- and/or extracellular medium composition in physiological processes. Motion artifacts and camera defaults may hinder the computation of the frequency variations during long ...
Meste, Olivier+2 more
openaire +3 more sources
Odd elastohydrodynamics: non-reciprocal living material in a viscous fluid [PDF]
Motility is a fundamental feature of living matter, encompassing single cells and collective behavior. Such living systems are characterized by non-conservativity of energy and a large diversity of spatio-temporal patterns. Thus, fundamental physical principles to formulate their behavior are not yet fully understood. This study explores a violation of
arxiv +1 more source
Electrical Signaling in Motile and Primary Cilia
Cilia are highly conserved for their structure and also for their sensory functions. They serve as antennae for extracellular information. Whether the cilia are motile or not, they respond to environmental mechanical and chemical stimuli and signal to the cell body.
Judith Van Houten, Steven J. Kleene
openaire +4 more sources
An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue [PDF]
BACKGROUND: Cilia are found on nearly every cell type in the mammalian body, and have been historically classified as either motile or immotile. Motile cilia are important for fluid and cellular movement; however, the roles of non-motile or primary cilia
Amber K O’Connor+9 more
core +1 more source
Amphibious Transport of Fluids and Solids by Soft Magnetic Carpets [PDF]
One of the major challenges in modern robotics is controlling micromanipulation by active and adaptive materials. In the respiratory system, such actuation enables pathogen clearance by means of motile cilia. While various types of artificial cilia have been engineered recently, they often involve complex manufacturing protocols and focus on ...
arxiv +1 more source
The motile cilium/flagellum is an ancient eukaryotic organelle. The molecular machinery of ciliary motility comprises a variety of cilium-specific dynein motor complexes along with other complexes that regulate their activity.
Petra zur Lage+2 more
doaj +1 more source
Wnt-PLC-IP3-Connexin-Ca2+ axis maintains ependymal motile cilia in zebrafish spinal cord
Ependymal cells (ECs) are multiciliated neuroepithelial cells that line the ventricles of the brain and the central canal of the spinal cord (SC). How ependymal motile cilia are maintained remains largely unexplored.
Jun Zhang+20 more
semanticscholar +1 more source
Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis [PDF]
The small GTP-binding protein Rab8 is known to play an essential role in intracellular transport and cilia formation. We have previously demonstrated that Rab8a is required for localising apical markers in various organisms.
A. Harada+10 more
core +2 more sources