Results 1 to 10 of about 11,872 (202)

The regulation of mechanosensory motile cilium formation [PDF]

open access: hybridCilia, 2015
In contrast to the progress in understanding ciliogenesis and cilium function, we know less about the pathways for generating ciliary diversity. Drosophila has a variety of sensory neurons with ciliary dendrites that are structurally and functionally specialised for receiving different sensory modalities.
Jarman A, Lage P, Mali G, Mill P.
europepmc   +5 more sources

Ciliary chemosensitivity is enhanced by cilium geometry and motility

open access: yeseLife, 2021
Cilia are hairlike organelles involved in both sensory functions and motility. We discuss the question of whether the location of chemical receptors on cilia provides an advantage in terms of sensitivity and whether motile sensory cilia have a further ...
David Hickey   +2 more
doaj   +5 more sources

The primary cilium as a multifunctional organelle: emerging roles and unanswered questions [PDF]

open access: yesCell Communication and Signaling
The primary cilium, a solitary membrane-bound, microtubule-based cellular organelle, has been considered an evolutionary relict for almost a century. Over the past three decades, interest in this protruding, non-motile structure of the plasma membrane ...
Denis Corbeil   +4 more
doaj   +2 more sources

Insights into centriole geometry revealed by cryotomography of doublet and triplet centrioles [PDF]

open access: yeseLife, 2018
Centrioles are cylindrical assemblies comprised of 9 singlet, doublet, or triplet microtubules, essential for the formation of motile and sensory cilia.
Garrett A Greenan   +3 more
doaj   +4 more sources

GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base

open access: yeseLife, 2022
The gap junction complex functions as a transport channel across the membrane. Among gap junction subunits, gap junction protein α1 (GJA1) is the most commonly expressed subunit.
Dong Gil Jang   +8 more
doaj   +1 more source

Forkhead transcription factor FKH-8 cooperates with RFX in the direct regulation of sensory cilia in Caenorhabditis elegans

open access: yeseLife, 2023
Cilia, either motile or non-motile (a.k.a primary or sensory), are complex evolutionarily conserved eukaryotic structures composed of hundreds of proteins required for their assembly, structure and function that are collectively known as the ciliome ...
Rebeca Brocal-Ruiz   +7 more
doaj   +1 more source

Pathophysiology of Primary Cilia: Signaling and Proteostasis Regulation

open access: yesFrontiers in Cell and Developmental Biology, 2022
Primary cilia are microtubule-based, non-motile sensory organelles present in most types of growth-arrested eukaryotic cells. They are transduction hubs that receive and transmit external signals to the cells in order to control growth, differentiation ...
Emanuela Senatore   +5 more
doaj   +1 more source

Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo

open access: yesBioengineering, 2022
Motile cilia are hair-like microscopic structures which generate directional flow to provide fluid transport in various biological processes. Ciliary beating is one of the sources of cerebrospinal flow (CSF) in brain ventricles.
Huseyin Enes Salman   +2 more
doaj   +1 more source

Integrative analysis of transcriptomic and metabolomic profiles reveals enhanced arginine metabolism in androgen-independent prostate cancer cells

open access: yesBMC Cancer, 2023
Background Prostate cancer is a common solid tumor that affects a significant number of men worldwide. Conventional androgen deprivation therapy (ADT) increases the risk of developing castration-resistant prostate cancer (CRPC).
Xingchen Dai   +4 more
doaj   +1 more source

Impaired Ciliary Beat Frequency and Ciliogenesis Alteration during Airway Epithelial Cell Differentiation in COPD

open access: yesDiagnostics, 2021
Chronic obstructive pulmonary disease (COPD) is a frequent respiratory disease. However, its pathophysiology remains partially elucidated. Epithelial remodeling including alteration of the cilium is a major hallmark of COPD, but specific assessments of ...
Julien Ancel   +10 more
doaj   +1 more source

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