Results 91 to 100 of about 11,920 (200)

Biciliated ependymal cell proliferation contributes to spinal cord growth [PDF]

, 2012
Two neurogenic regions have been described in the adult brain, the lateral ventricle subventricular zone and the dentate gyrus subgranular zone. It has been suggested that neural stem cells also line the central canal of the adult spinal cord.
Alfaro-Cervello, Alvarez-Buylla, Alvarez-Buylla, Alvarez-Dolado, Anastas, Barber, Basto, Beattie, Bjugn, Bradbury, Brandt, Brown, Bruni, Capela, Chiasson, Crespo, Das, Debus, Dirksen, Doetsch, Doetsch, Doetsch, Dromard, Gerdes, Goetz, Gonzalez-Perez, Gritti, Hamilton, Han, Hinchcliffe, Hockfield, Horner, Huang, Jacquet, Kee, Kerever, Khodjakov, Khodjakov, Kojima, Komatsu, Komitova, Kramer-Zucker, LaMotte, Laywell, Lendahl, Lois, Luo, Magrassi, Marichal, Marshall, Martens, Meletis, Menn, Mercier, Mirzadeh, Mirzadeh, Mothe, Nakayama, Namiki, Nonaka, Oakley, Otani, Peters, Poppleton, Rafols, Rawlins, Russell, Sabourin, Sanai, Satir, Seitz, Shen, Shibuya, Sorokin, Spassky, Vigh, Weigmann, Weiss, Wong, Zhang   +79 more
core   +1 more source

Post‐LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor

Cytoskeleton, EarlyView.
ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
Stephen M. King
wiley   +1 more source

The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium [PDF]

, 2014
The primary cilium has an important role in signaling; defects in structure are associated with a variety of human diseases. Much of the most basic biology of this organelle is poorly understood, even basic mechanisms, such as control of growth and ...
Kirschner, Marc W, Wang, Weiping, Wu, Tao   +2 more
core   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Repression of GW/P body components and the RNAi microprocessor impacts primary ciliogenesis in human astrocytes

BMC Cell Biology, 2011
Background In most cells, the centriolar component of the centrosome can function as a basal body supporting the formation of a primary cilium, a non-motile sensory organelle that monitors information from the extracellular matrix and relays stimuli into
Rattner Jerome B, Fritzler Marvin J, Moser Joanna J   +2 more
doaj   +1 more source

Resting cells rely on the DNA helicase component MCM2 to build cilia [PDF]

, 2019
Minichromosome maintenance (MCM) proteins facilitate replication by licensing origins and unwinding the DNA double strand. Interestingly, the number of MCM hexamers greatly exceeds the number of firing origins suggesting additional roles of MCMs. Here we
Alcantara, Alver, Amack, Amsterdam, Anders, Arnaiz, Avila, Bailey, Bailey, Belmont, Bentley, Bettencourt-Dias, Bicknell, Bochman, Bochman, Buenrostro, Burkhalter, Campos, Casar Tena, Chen, Chuang, Cornelia Donow, Dasgupta, Drissi, Dubois, Essner, Evrin, Ferguson, Gerdes, Gineau, Goetz, Grimes, Hamada, Hemerly, Hiraga, Holland, Hughes, Ibarra, Ishikawa, Ishimi, Karol Szafranski, Kim, Kim, Kong, Kunnev, Labib, Langley, Langmead, Lars D Maerz, Li, Li, Liao, Long, Mahjoub, Maine, Marco Groth, Maric, Maric, Marshall, Martin D Burkhalter, Melanie Philipp, Micklem, Miotto, Mukhopadhyay, Mullee, Nguyen, Paul Walther, Penelope A Jeggo, Petryk, Philipp, Philipp, Prasanth, Praveen, Prioleau, Prokhortchouk, Pruitt, Pugacheva, Rainey, Rice, Robinson, Rusiniak, Ruzov, Ruzov, Sabrina Matysik, Sanchez, Schneider, Sheu, Shukla, Soung, Stelzer, Stiff, Stiff, Stuermer, Sugimoto, Takahashi, Tamara J Blätte, Tanos, Tena, Teresa Casar Tena, Thisse, Todorov, Vijayraghavan, Walther, Wei, Zhang, Zhang, Zhou   +106 more
core   +1 more source

Evaluation of Acute Exposure to Combustible and Novel Tobacco Products Using an In Vitro Human Airway Organ Tissue Equivalent Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Despite the well‐known risks of tobacco use, tobacco exposure remains a major contributor to morbidity and mortality worldwide. Although cigarette use has declined, the popularity of novel tobacco products (NTPs), such as electronic cigarettes (ECs) and heated tobacco products (HTPs), has increased.
Timothy S. Leach, Steven Albertson, Phillip W. Clapp, Vikram Surendran, Trang Simon, Eric C. Donny, Stephen J. Walker, Anthony Atala, Sean V. Murphy   +8 more
wiley   +1 more source

Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome

Disease Models & Mechanisms, 2011
SUMMARY Meckel-Gruber syndrome (MKS) is a recessive disorder resulting in multiple birth defects that are associated with mutations affecting ciliogenesis.
Cheng Cui, Bishwanath Chatterjee, Deanne Francis, Qing Yu, Jovenal T. SanAgustin, Richard Francis, Terry Tansey, Charisse Henry, Baolin Wang, Bethan Lemley, Gregory J. Pazour, Cecilia W. Lo   +11 more
doaj   +1 more source

Case series: Joubert syndrome and eosinophilic esophagitis

JPGN Reports, EarlyView.
Abstract Joubert syndrome (JS) is a rare genetic disorder characterized by developmental abnormalities, particularly in the brainstem and cerebellar vermis, alongside multisystem manifestations such as kidney and liver anomalies, polydactyly, cleft lip or palate, and tongue defects.
Jonathon Schening, Stephanie Leon‐Paredes, Eric Chiou, Vibha Szafron, Anthony Olive, Sara Anvari   +5 more
wiley   +1 more source

Epigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

Respirology, EarlyView.
This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.
Ayaka Shiota, Keiko Kan‐o, Yumiko Ishii, Tomoaki Koga, Takeshi Sawada, Kei‐ichiro Yasunaga, Shingo Usuki, Tatsuya Katsuno, Shigesato Inoue, Tomohiro Ogawa, Akihiro Jo, Satoru Fukuyama, Mitsuyoshi Nakao, Hiroaki Ogata, Mizuho A. Kido, Sachiko Tsukita, Koichiro Matsumoto, Isamu Okamoto   +17 more
wiley   +1 more source