Results 111 to 120 of about 11,920 (200)

Mouse genome engineering uncovers 18 genes dispensable for male reproduction

Andrology, EarlyView.
Abstract Background Male infertility is an intricate multifactorial disease involving the interplay between genetic and environmental factors. Genetic anomalies account for more than 15% of all male infertility cases; however, diagnosing them exhibits enormous challenges due to variable symptomatic presentations and limited knowledge of gene functions.
Hsin‐Yi Chang, Yonggang Lu, Kaito Yamamoto, Jiang Sun, Keisuke Shimada, Yuki Hiradate, Yoshitaka Fujihara, Masahito Ikawa   +7 more
wiley   +1 more source

Microtubule Inner Protein CFAP77 Contributes to Sperm Motility and Male Fertility in Mice

Andrology, EarlyView.
ABSTRACT Background Sperm motility is essential for male fertility, and its regulation is dependent on the structural integrity of the axoneme. The axoneme consists of a conserved “9+2” microtubule arrangement and is supported by microtubule inner proteins. However, the functional significance of many microtubule inner proteins remains unclear.
Haoting Wang, Anh Hoang Pham, Mengjiao Luo, Masahito Ikawa, Haruhiko Miyata   +4 more
wiley   +1 more source

TGF-β Signaling Regulates the Differentiation of Motile Cilia

Cell Reports, 2015
The cilium is a small cellular organelle with motility- and/or sensory-related functions that plays a crucial role during developmental and homeostatic processes.
Janos Tözser, Ryan Earwood, Akiko Kato, Jacob Brown, Koichi Tanaka, Ruth Didier, Timothy L. Megraw, Martin Blum, Yoichi Kato   +8 more
doaj   +1 more source

Comprehensive Quantification of Oligoasthenozoospermia Induced by Obesity, Reproductive Toxicants, and Their Combination in Rat Models

Andrology, EarlyView.
ABSTRACT Background Oligoasthenozoospermia is a leading cause of male infertility and has been increasingly associated with the global surge in obesity and exposure to reproductive toxicants. Despite extensive research on each factor individually, their combined pathological effects remain poorly understood.
Yunlong Yao, Xi Zhang, Lingru Li, Yunzhi Zhang, Shuo Huang, Yulin Zong, Mingrui Li, Fufangyu Zhao, Linghui Zhu, Tianxing Li, Wenlong Sun, Mingyan Shao, Yanfei Zheng   +12 more
wiley   +1 more source

Primary ciliogenesis defects are associated with human astrocytoma/glioblastoma cells

BMC Cancer, 2009
Background Primary cilia are non-motile sensory cytoplasmic organelles that have been implicated in signal transduction, cell to cell communication, left and right pattern embryonic development, sensation of fluid flow, regulation of calcium levels ...
Rattner Jerome B, Fritzler Marvin J, Moser Joanna J   +2 more
doaj   +1 more source

Outcomes and complications of sponges versus tires for scleral buckling in primary rhegmatogenous retinal detachment: The Manchester Buckle Study

Acta Ophthalmologica, EarlyView.
Abstract Purpose To compare preoperative characteristics and postoperative anatomical and functional outcomes of scleral buckle surgery using sponges versus tires, as well as explant‐related complications and the frequency of explant removal. Methods This retrospective study included patients with primary rhegmatogenous retinal detachment (RRD) who ...
Peter Kiraly, Myrta Lippera, Naseer Ally, Ritu Agarwal, George Moussa, Tsveta Ivanova, Felipe Dhawahir‐Scala, Niall Patton, George Turner, Stephen Charles, Assad Jalil, Kirti M. Jasani   +11 more
wiley   +1 more source

Cilia beating misalignment, immotility or death pathologically affect the efficiency of mucus-clearance

Communications Physics
To perform mucociliary clearance, motile cilia covering the surface of the respiratory tract coordinate their beating motions to push mucus out of the upper airways.
Émeline Laborie, Simone Melchionna, Fabio Sterpone   +2 more
doaj   +1 more source

DPY-30 Domain and its Flanking Sequence Mediate the Assembly Modulation of Flagellar Radial Spoke Complexes [PDF]

, 2012
RIIa is known as the dimerization and docking (D/D) domain of the cyclic AMP (cAMP)-dependent protein kinase. However, numerous molecules, including radial spoke protein 2 (RSP2) in Chlamydomonas flagella, also contain an RIIa or a similar DPY-30 domain.
Foster, Kenneth W., Gopal, Radhika, Yang, Pinfen   +2 more
core   +1 more source

A highly abundant circular RNA from the RMST locus plays a role in posterior fossa ependymoma pathogenesis

Brain Pathology, EarlyView.
circRMST (hsa_circ_0099634) is by far the most abundant isoform from the RMST locus. It is highly expressed in cancer cells throughout ependymoma patient samples and is located in the cytoplasm. circRMST knockdown causes cell cycle arrest and induces differentiation, and it is a marker for poor prognosis. The figure is made using BioRender.
Ulvi Ahmadov, Charlotte W. Udengaard, Stine M. Vissing, Silke D. Nielsen, Kim‐Gwendolyn Dietrich, Benedicte Parm Ulhøi, Lasse S. Kristensen   +6 more
wiley   +1 more source

Interpreting the synchronisation of driven colloidal oscillators via the mean pair interaction

New Journal of Physics, 2018
To explore the generic features of synchronisation facilitated by hydrodynamic interactions dominated by viscous forces, we investigate small systems of rowers; rowers are a highly simplified model for motile cilia, with each cilium approximated by a ...
E Hamilton, P Cicuta
doaj   +1 more source