Concurrent Actuation and Sensing in Fluid by Cilia‐Like Transducers
Advanced Intelligent Systems, 2023 Motile cilia are miniature, hair‐like organelles whose beating moves fluid in various organisms and the human body. Motile cilia are also able to sense many mechanical or fluidic cues.
Wenkang Wang, Shanyuan Song, Wenqi Hu
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CPLANE Complex and Ciliopathies
Biomolecules, 2022 Primary cilia are non-motile organelles associated with the cell cycle, which can be found in most vertebrate cell types. Cilia formation occurs through a process called ciliogenesis, which involves several mechanisms including planar cell polarity (PCP)
Jesús Eduardo Martín-Salazar +1 more
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Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish [PDF]
, 2010 Background: In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway.
Ingham, P.W. +3 more
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Advances in Understanding the Genetic Mechanisms of Zebrafish Renal Multiciliated Cell Development
Journal of Developmental Biology, 2022 Cilia are microtubule-based organelles that project from the cell surface. In humans and other vertebrates, possession of a single cilium structure enables an assortment of cellular processes ranging from mechanosensation to fluid propulsion and ...
Hannah M. Wesselman +4 more
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Ciliary Assembly/Disassembly Assay in Non-transformed Cell Lines
Bio-Protocol, 2018 The primary cilium is a non-motile sensory organelle whose assembly and disassembly are closely associated with cell cycle progression. The primary cilium is elongated from the basal body in quiescent cells and is resorbed as the cells re-enter the cell ...
Masaki Saito +3 more
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Neuronal primary cilia integrate peripheral signals with metabolic drives
Frontiers in Physiology, 2023 Neuronal primary cilia have recently emerged as important contributors to the central regulation of energy homeostasis. As non-motile, microtubule-based organelles, primary cilia serve as signaling antennae for metabolic status. The impairment of ciliary
Kelly M. DeMars +4 more
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Heat shock induces rapid resorption of primary cilia [PDF]
, 2012 Primary cilia are involved in important developmental and disease pathways, such as the regulation of neurogenesis and tumorigenesis. They function as sensory antennae and are essential in the regulation of key extracellular signalling systems.
Anckar +32 more
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A Model for the Force Exerted on a Primary Cilium by an Optical Trap and the Resulting Deformation
Photonics, 2015 Cilia are slender flexible structures extending from the cell body; genetically similar to flagella. Although their existence has been long known, the mechanical and functional properties of non-motile (“primary”) cilia are largely unknown. Optical traps
Ian Lofgren, Andrew Resnick
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IFT74 variants cause skeletal ciliopathy and motile cilia defects in mice and humans.
PLoS Genetics, 2023 Motile and non-motile cilia play critical roles in mammalian development and health. These organelles are composed of a 1000 or more unique proteins, but their assembly depends entirely on proteins synthesized in the cell body and transported into the ...
Zeineb Bakey +25 more
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A novel function of Huntingtin in the cilium and retinal ciliopathy in Huntington's disease mice
Neurobiology of Disease, 2015 Huntington's disease (HD) is a neurodegenerative disorder caused by the toxic expansion of polyglutamine in the Huntingtin (HTT) protein. The pathomechanism is complex and not fully understood.
Alice Karam +7 more
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