Results 21 to 30 of about 56,795 (179)

Nonreciprocal interactions give rise to fast cilium synchronization in finite systems [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Motile cilia are hairlike organelles that, at sufficient density, can synchronize hydrodynamically with their neighbors to form a metachronal wave. We use a minimal model of a ciliary carpet that accounts for near-field hydrodynamic coupling
David Hickey, R. Golestanian, A. Vilfan
semanticscholar   +1 more source

GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base

eLife, 2022
The gap junction complex functions as a transport channel across the membrane. Among gap junction subunits, gap junction protein α1 (GJA1) is the most commonly expressed subunit.
Dong Gil Jang, Keun Yeong Kwon, Yeong Cheon Kweon, Byung-gyu Kim, Kyungjae Myung, Hyun-Shik Lee, Chan Young Park, Taejoon Kwon, Tae Joo Park   +8 more
doaj   +1 more source

Forkhead transcription factor FKH-8 cooperates with RFX in the direct regulation of sensory cilia in Caenorhabditis elegans

eLife, 2023
Cilia, either motile or non-motile (a.k.a primary or sensory), are complex evolutionarily conserved eukaryotic structures composed of hundreds of proteins required for their assembly, structure and function that are collectively known as the ciliome ...
Rebeca Brocal-Ruiz, Ainara Esteve-Serrano, Carlos Mora-Martínez, Maria Luisa Franco-Rivadeneira, Peter Swoboda, Juan J Tena, Marçal Vilar, Nuria Flames   +7 more
doaj   +1 more source

Pathophysiology of Primary Cilia: Signaling and Proteostasis Regulation

Frontiers in Cell and Developmental Biology, 2022
Primary cilia are microtubule-based, non-motile sensory organelles present in most types of growth-arrested eukaryotic cells. They are transduction hubs that receive and transmit external signals to the cells in order to control growth, differentiation ...
Emanuela Senatore, Rosa Iannucci, Francesco Chiuso, Rossella Delle Donne, Laura Rinaldi, Antonio Feliciello   +5 more
doaj   +1 more source

Integrative analysis of transcriptomic and metabolomic profiles reveals enhanced arginine metabolism in androgen-independent prostate cancer cells

BMC Cancer, 2023
Background Prostate cancer is a common solid tumor that affects a significant number of men worldwide. Conventional androgen deprivation therapy (ADT) increases the risk of developing castration-resistant prostate cancer (CRPC).
Xingchen Dai, Xinyi Shi, Mingxiu Luo, Pu Li, Yujing Gao   +4 more
doaj   +1 more source

Impaired Ciliary Beat Frequency and Ciliogenesis Alteration during Airway Epithelial Cell Differentiation in COPD

Diagnostics, 2021
Chronic obstructive pulmonary disease (COPD) is a frequent respiratory disease. However, its pathophysiology remains partially elucidated. Epithelial remodeling including alteration of the cilium is a major hallmark of COPD, but specific assessments of ...
Julien Ancel, Randa Belgacemi, Zania Diabasana, Jeanne-Marie Perotin, Arnaud Bonnomet, Maxime Dewolf, Claire Launois, Pauline Mulette, Gaëtan Deslée, Myriam Polette, Valérian Dormoy   +10 more
doaj   +1 more source

The Male Mouse Meiotic Cilium Emanates from the Mother Centriole at Zygotene Prior to Centrosome Duplication

bioRxiv, 2022
Cilia are hair-like projections of the plasma membrane with an inner microtubule skeleton known as axoneme. Motile cilia and flagella beat to displace extracellular fluids, playing important roles in the airways and reproductive system, among others ...
P. López-Jiménez, S. Pérez-Martín, Inés Hidalgo, F. Garcia-Gonzalo, J. Page, R. Gómez   +5 more
semanticscholar   +1 more source

Interpreting the pathogenicity of Joubert syndrome missense variants in Caenorhabditis elegans

Disease Models & Mechanisms, 2021
Ciliopathies are inherited disorders caused by defects in motile and non-motile (primary) cilia. Ciliopathy syndromes and associated gene variants are often highly pleiotropic and represent exemplars for interrogating genotype-phenotype correlations ...
Karen I. Lange, Sofia Tsiropoulou, Katarzyna Kucharska, Oliver E. Blacque   +3 more
doaj   +1 more source

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development.

Journal of Visualized Experiments, 2022
Primary cilia (PC) are non-motile dynamic microtubule-based organelles that protrude from the surface of most mammalian cells. They emerge from the older centriole during the G1/G0 phase of the cell cycle, while they disassemble as the cells re-enter the
Lucile Boutaud, Marie Michael, Céline Banal, D. Calderon, Sarah Farcy, J. Pernelle, Nicolas Goudin, Camille Maillard, C. Dimartino, Cécile Deleschaux, Sébastien Dupichaud, Corinne Lebreton, S. Saunier, T. Attié-Bitach, N. Bahi-Buisson, N. Lefort, Sophie Thomas   +16 more
semanticscholar   +1 more source

Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish [PDF]

, 2010
Background: In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway.
Ingham, P.W., Kim, H.R., Richardson, J., van Eeden, F.   +3 more
core   +3 more sources