Results 31 to 40 of about 58,452 (246)
C. elegans PPEF-type phosphatase (Retinal degeneration C ortholog) functions in diverse classes of cilia to regulate nematode behaviors [PDF]
Scientific ReportsPrimary (non-motile) cilia represent structurally and functionally diverse organelles whose roles as specialized cellular antenna are central to animal cell signaling pathways, sensory physiology and development.
Marine Barbelanne +9 more
doaj +2 more sources
Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications. [PDF]
Adv Sci (Weinh)HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Wang Z +5 more
europepmc +2 more sources
Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry [PDF]
, 2016 The establishment of left–right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and ...
Betleja, Ewelina +8 more
core +2 more sources
CPLANE Complex and Ciliopathies
Biomolecules, 2022 Primary cilia are non-motile organelles associated with the cell cycle, which can be found in most vertebrate cell types. Cilia formation occurs through a process called ciliogenesis, which involves several mechanisms including planar cell polarity (PCP)
Jesús Eduardo Martín-Salazar +1 more
doaj +1 more source
Heat shock induces rapid resorption of primary cilia [PDF]
, 2012 Primary cilia are involved in important developmental and disease pathways, such as the regulation of neurogenesis and tumorigenesis. They function as sensory antennae and are essential in the regulation of key extracellular signalling systems.
Anckar +32 more
core +1 more source
Highly motile nanoscale magnetic artificial cilia
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Cilia are hair-like microscopic structures present abundantly in our body and producing motions at the smallest scales. They perform a wide range of critical functions and are crucial for the normal functioning of our body.
Tanveer ul Islam +2 more
semanticscholar +1 more source
Concurrent Actuation and Sensing in Fluid by Cilia‐Like Transducers
Advanced Intelligent Systems, 2023 Motile cilia are miniature, hair‐like organelles whose beating moves fluid in various organisms and the human body. Motile cilia are also able to sense many mechanical or fluidic cues.
Wenkang Wang, Shanyuan Song, Wenqi Hu
doaj +1 more source
Advances in Understanding the Genetic Mechanisms of Zebrafish Renal Multiciliated Cell Development
Journal of Developmental Biology, 2022 Cilia are microtubule-based organelles that project from the cell surface. In humans and other vertebrates, possession of a single cilium structure enables an assortment of cellular processes ranging from mechanosensation to fluid propulsion and ...
Hannah M. Wesselman +4 more
doaj +1 more source
A systems-biology approach to understanding the ciliopathy disorders. [PDF]
, 2011 'Ciliopathies' are an emerging class of genetic multisystemic human disorders that are caused by a multitude of largely unrelated genes that affect ciliary structure/function.
Gleeson, Joseph G, Lee, Ji Eun
core +1 more source
Molecular Biology of the Cell, 2021 Motile cilia of multiciliated epithelial cells undergo synchronized beating to produce fluid flow along the luminal surface of various organs. Each motile cilium consists of an axoneme and a basal body (BB), which are linked by a “transition zone” (TZ ...
H. Saito +15 more
semanticscholar +1 more source