Neuronal primary cilia integrate peripheral signals with metabolic drives
Frontiers in Physiology, 2023 Neuronal primary cilia have recently emerged as important contributors to the central regulation of energy homeostasis. As non-motile, microtubule-based organelles, primary cilia serve as signaling antennae for metabolic status. The impairment of ciliary
Kelly M. DeMars +4 more
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Reactivation of ethanol-calcium-isolated cilia from Tetrahymena pyriformis [PDF]
, 1967 Cilia isolated from Tetrahymena after ciliary shedding is induced by the addition of CaCl2 or other salts to cells suspended in an ethanol solution (4, 6, 11) have been studied chemically and enzymatically (4, 6, 11, 12, 13), but until now have never ...
Winicur, Sandra
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Ciliary Assembly/Disassembly Assay in Non-transformed Cell Lines
Bio-Protocol, 2018 The primary cilium is a non-motile sensory organelle whose assembly and disassembly are closely associated with cell cycle progression. The primary cilium is elongated from the basal body in quiescent cells and is resorbed as the cells re-enter the cell ...
Masaki Saito +3 more
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Symmetry Breaking in a Model for Nodal Cilia [PDF]
, 2005 Nodal cilia are very short cilia found in the embryonic node on the ventral surface of early mammalian embryos. They create a right to left fluid flow that is responsible for determining the normal asymmetry of the internal organs of the mammalian body ...
Brokaw, Charles J.
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A Model for the Force Exerted on a Primary Cilium by an Optical Trap and the Resulting Deformation
Photonics, 2015 Cilia are slender flexible structures extending from the cell body; genetically similar to flagella. Although their existence has been long known, the mechanical and functional properties of non-motile (“primary”) cilia are largely unknown. Optical traps
Ian Lofgren, Andrew Resnick
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Exploring the role of fallopian ciliated cells in the pathogenesis of high-grade serous ovarian cancer [PDF]
, 2018 High-grade serous epithelial ovarian cancer (HGSOC) is the fifth leading cause of cancer death in women and the first among gynecological malignancies. Despite an initial response to standard chemotherapy, most HGSOC patients relapse.
Baldassarre G +9 more
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Information and motility exchange in collectives of active particles [PDF]
Soft Matter, 2020, Advance Article, 2020 We examine the interplay of motility and information exchange in a model of run-and-tumble active particles where the particle's motility is encoded as a bit of information that can be exchanged upon contact according to the rules of AND and OR logic gates in a circuit.
arxiv +1 more source
Mixing and transport by ciliary carpets: a numerical study [PDF]
, 2013 We use a 3D computational model to study the fluid transport and mixing due to the beating of an infinite array of cilia. In accord with recent experiments, we observe two distinct regions: a fluid transport region above the cilia and a fluid mixing ...
Ding, Yang +3 more
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Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina:insights into X-linked Retinitis Pigmentosa and associated ciliopathies [PDF]
, 2008 Mutations in the cilia-centrosomal protein Retinitis Pigmentosa GTPase Regulator (RPGR) are a frequent cause of retinal degeneration. The RPGR gene undergoes complex alternative splicing and encodes multiple protein isoforms. To elucidate the function of
Akimoto +80 more
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Evaluating efficiency and robustness in cilia design [PDF]
Phys. Rev. E 93, 033119 (2016), 2015 Motile cilia are used by many eukaryotic cells to transport flow. Cilia-driven flows are important to many physiological functions, yet a deep understanding of the interplay between the mechanical structure of cilia and their physiological functions in healthy and diseased conditions remains elusive.
arxiv +1 more source