Results 51 to 60 of about 58,452 (246)

Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy

Cells, 2020
Ciliopathies are a group of human genetic disorders associated with mutations that give rise to the dysfunction of primary cilia. Ciliogenesis-associated kinase 1 (CILK1), formerly known as intestinal cell kinase (ICK), is a conserved serine and ...
Eric J. Wang, Casey D. Gailey, David L. Brautigan, Zheng Fu   +3 more
doaj   +1 more source

Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia

Frontiers in Cell and Developmental Biology, 2021
Cilia are evolutionarily highly conserved organelles with important functions in many organs. The extracellular component of the cilium protruding from the plasma membrane comprises an axoneme composed of microtubule doublets, arranged in a 9 + 0 ...
Paweł K. Łysyganicz, Paweł K. Łysyganicz, Niedharsan Pooranachandran, Xinming Liu, Kathryn I. Adamson, Kathryn I. Adamson, Katarzyna Zielonka, Katarzyna Zielonka, Stone Elworthy, Stone Elworthy, Fredericus J. van Eeden, Fredericus J. van Eeden, Andrew J. Grierson, Andrew J. Grierson, Jarema J. Malicki, Jarema J. Malicki   +15 more
doaj   +1 more source

Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2 [PDF]

, 2012
Unidirectional fluid flow plays an essential role in the breaking of left-right (L-R) symmetry in mouse embryos, but it has remained unclear how the flow is sensed by the embryo.
A. Kawasumi, B. Dworniczak, B. E. Ehrlich, Collignon, Ermakov, G. Sasaki, Gonzalez-Perrett, H. Hamada, H. Sasaki, H. Shiratori, Hirokawa, I. Y. Kuo, J. A. Belo, J. Nakai, K. Shinohara, Koulen, Marques, Marszalek, McGrath, Nauli, Nonaka, P. Pennekamp, Pazour, Pennekamp, Rankin, REYNOLDS, S. Nonaka, S. Yoshiba, Schweickert, Shinohara, Tabin, Tanaka, Tanaka, Y. Asai   +33 more
core   +1 more source

Signaling in the primary cilium through the lens of the Hedgehog pathway

Wiley Interdisciplinary Reviews: Developmental Biology, 2020
Cilia are microtubule‐based, cell‐surface projections whose machinery is evolutionarily conserved. In vertebrates, cilia are observed on almost every cell type and are either motile or immotile.
E. Gigante, T. Caspary
semanticscholar   +1 more source

Tracheal motile cilia in mice require CAMSAP3 for formation of central microtubule pair and coordinated beating

bioRxiv, 2021
Motile cilia of multiciliated epithelial cells undergo synchronized beating to produce fluid flow along the luminal surface of various organs. Each motile cilium consists of an axoneme and a basal body, which are linked by a ‘transition zone’.
H. Saito, Fumiko Matsukawa-Usami, T. Fujimori, Toshiya Kimura, Takahiro Ide, Takaki Yamamoto, T. Shibata, Kenta Onoue, S. Okayama, S. Yonemura, K. Misaki, Yurina Soba, Yasutaka Kakui, Masamitsu Sato, M. Toya, M. Takeichi   +15 more
semanticscholar   +1 more source

Dynamics of cilia length in left–right development [PDF]

Royal Society Open Science, 2017
Reduction in the length of motile cilia in the zebrafish left–right organizer (LRO), also known as Kupffer's vesicle, has a large impact on left–right development.
P. Pintado, P. Sampaio, B. Tavares, T. D. Montenegro-Johnson, D. J. Smith, S. S. Lopes   +5 more
doaj   +1 more source

Modelling the Fluid Mechanics of Cilia and Flagella in Reproduction and Development [PDF]

Montenegro-Johnson et al, Eur. Phys. J. E, 35 10 (2012) 111, 2013
Cilia and flagella are actively bending slender organelles, performing functions such as motility, feeding and embryonic symmetry breaking. We review the mechanics of viscous-dominated microscale flow, including time-reversal symmetry, drag anisotropy of slender bodies, and wall effects.
arxiv   +1 more source

Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease. [PDF]

PLoS Genetics, 2016
Ciliopathies are genetic disorders arising from dysfunction of microtubule-based cellular appendages called cilia. Different cilia types possess distinct stereotypic microtubule doublet arrangements with non-motile or 'primary' cilia having a 9+0 and ...
Wesley R Lewis, Erik B Malarkey, Douglas Tritschler, Raqual Bower, Raymond C Pasek, Jonathan D Porath, Susan E Birket, Sophie Saunier, Corinne Antignac, Michael R Knowles, Margaret W Leigh, Maimoona A Zariwala, Anil K Challa, Robert A Kesterson, Steven M Rowe, Iain A Drummond, John M Parant, Friedhelm Hildebrandt, Mary E Porter, Bradley K Yoder, Nicolas F Berbari   +20 more
doaj   +1 more source

Tubulin Polymerization Promoting Proteins (TPPPs) of Aphelidiomycota: Correlation between the Incidence of p25alpha Domain and the Eukaryotic Flagellum

Journal of Fungi, 2023
The seven most early diverging lineages of the 18 phyla of fungi are the non-terrestrial fungi, which reproduce through motile flagellated zoospores. There are genes/proteins that are present only in organisms with flagellum or cilium.
Ferenc Orosz
doaj   +1 more source

STUDIES ON CILIA [PDF]

The Journal of Cell Biology, 1963
Upon excision into spring water, the lateral cilia of the gill of the freshwater mussel Elliptio complanatus (Solander) stop beating, but 0.04 M potassium ion can activate the gill so that these cilia again beat with metachronal rhythm. One per cent osmium tetroxide quickly pipetted onto a fully activated gill fixes the lateral cilia in a pattern that ...
openaire   +7 more sources