Results 81 to 90 of about 11,920 (200)

Animal models of benign airway stenosis: Advances in construction techniques, evaluation systems, and perspectives

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Currently, the animals commonly used to establish animal models of benign airway stenosis (BAS) include mice, rats, pigs, dogs, rabbits, and ferrets. The establishment methods involve one or a combination of two methods such as mechanical injury, tracheal cautery, cuff overpressure intubation, laser injury, and endoscopic silver nitrate cauterization ...
Wusheng Zhang   +6 more
wiley   +1 more source

The centrosomal protein pericentrin identified at the basal body complex of the connecting cilium in mouse photoreceptors. [PDF]

open access: yesPLoS ONE, 2011
BACKGROUND: Pericentrin (Pcnt), a conserved protein of the pericentriolar material, serves as a multifunctional scaffold for numerous proteins and plays an important role in microtubule organization.
Johanna Mühlhans   +2 more
doaj   +1 more source

Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease [PDF]

open access: yes, 2017
The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder due to mutations in the NPC1 gene, encoding a transmembrane protein related to the Sonic hedgehog receptor, Patched, and involved in intracellular trafficking of ...
Canterini, Sonia   +7 more
core   +1 more source

Flow of Elastoviscous Nanofluid Through an Elongating Surface With Dissipative Heat: A Confluent Hypergeometric Solution

open access: yesAsia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Thermal energy transport likely through polymer extrusion, cooling of metallic plates, and chemical processing equipment relating to the flow of viscoelastic nanofluid has a greater role in engineering because of its elastic characteristics.
Rupa Baithalu   +3 more
wiley   +1 more source

Functional CRISPR‐Cas9 knockout screening of the genetic determinants of human fibroblast migration propensity

open access: yesBiotechnology Progress, EarlyView.
Abstract Directional cell migration plays a central role in a wide range of physiological and pathological conditions, such as embryonic development or tumor metastasis. Steps involved in cell migration include cell polarization, formation of membrane protrusions at the cell front side and adhesion disassembly at the rear side, and a general ...
Antonio Mazzei   +5 more
wiley   +1 more source

LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation

open access: yesCytoskeleton, EarlyView.
ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda   +4 more
wiley   +1 more source

Biological Fluid Mechanics Under the Microscope: A Tribute to John Blake

open access: yes, 2018
John Blake (1947--2016) was a leader in fluid mechanics, his two principal areas of expertise being biological fluid mechanics on microscopic scales and bubble dynamics. He produced leading research and mentored others in both Australia, his home country,
Smith, David J.
core   +1 more source

Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation [PDF]

open access: yes, 2015
Funded by Marie Curie Intra European Fellowship (GENOMICDIFF) Wellcome Trust ...
Chapple, JP   +4 more
core   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

open access: yesCytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius   +6 more
wiley   +1 more source

Anomalies in Dopamine Transporter Expression and Primary Cilium Distribution in the Dorsal Striatum of a Mouse Model of Niemann-Pick C1 Disease

open access: yesFrontiers in Cellular Neuroscience, 2019
The Niemann-Pick type C1 (NPC1) is a rare genetic disease characterized by the accumulation of endocytosed cholesterol and other lipids in the endosome/lysosome compartments.
Micaela Lucarelli   +6 more
doaj   +1 more source

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