Results 111 to 120 of about 3,006,826 (294)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Evaluation of Recurrent Takotsubo Syndrome

JACC: Advances
Background: After an initial Takotsubo syndrome (TTS) event, there is growing recognition of adverse long-term outcomes, including recurrent TTS events. Recurrent events have been incompletely evaluated.
Paul Marano, MD, Jenna Maughan, BA, Okezi Obrutu, MBBS, MPH, Marie Lauzon, MS, Benita Tjoe, MD, Romana Herscovici, MD, Prizzi Moy, BA, Natalie Rojas, AA, Chrisandra Shufelt, MD, MS, Thomas Rutledge, PhD, Janet Wei, MD, C. Noel Bairey Merz, MD   +11 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Optimization of brain PET markerless head motion correction in a large human cohort

EJNMMI Physics
Purpose Uncorrected head motion in brain PET degrades image resolution and biases quantification. Previously, we evaluated the United Imaging Healthcare markerless motion tracking (UMT) system for brain PET (Baseline UMT). This study provides an expanded
Tianyi Zeng, Jiazhen Zhang, Jean-Dominique Gallezot, Kathryn Fontaine, Weize Jiang, Paul Gravel, Tim Mulnix, Mika Naganawa, Zhaohui Yang, Xinyue Zhang, Su Wang, Xishan Sun, Lingzhi Hu, Richard E. Carson   +13 more
doaj   +1 more source

MSF: Multi-Level Spatiotemporal Filtering for Event Denoising via Motion Estimation

Sensors
Event cameras provide microsecond-level temporal resolution, low latency, and high dynamic range, enabling robust perception under fast motion and challenging lighting conditions.
Jiuhe Wang, Kun Yu, Xinghua Xu, Nanliang Shan   +3 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Seeing Motion at Nighttime with an Event Camera

2024 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR)
We focus on a very challenging task: imaging at nighttime dynamic scenes. Most previous methods rely on the low-light enhancement of a conventional RGB camera. However, they would inevitably face a dilemma between the long exposure time of nighttime and the motion blur of dynamic scenes.
Haoyue Liu 0001, Shihan Peng, Lin Zhu 0012, Yi Chang 0002, Hanyu Zhou, Luxin Yan   +5 more
openaire   +2 more sources

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Event-Triggered H∞Controller for a Semi-active Seat Suspension to Enhance Motion Comfort of Automated Vehicles

, 2022
This article proposes a disturbance observer-based event-triggered H∞ controller for a semi-active seat suspension that equips an advanced electromagnetic damper (EMD) system.
Xiangjun Xia (20255898), Haiping Du (6500786), Nong Zhang (40289), Minyi Zheng (20232450), Georgios Papaioannou (14821156), Donghong Ning (20051157)   +5 more
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source