Results 91 to 100 of about 3,290,391 (380)

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

open access: yesFEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker   +8 more
wiley   +1 more source

On Mach's critique of Newton and Copernicus

open access: yes, 2003
Maintaining the relativity of all motion, especially rotational motion, Mach denied the existence of absolute motion and absolute space. He maintained the equivalence of the Ptolemaic and the Copernican systems and the equivalence of a fixed bucket in a ...
Hartman, Herbert I.   +1 more
core   +1 more source

Research of Simulation in Character Animation Based on Physics Engine

open access: yesInternational Journal of Digital Multimedia Broadcasting, 2017
Computer 3D character animation essentially is a product, which is combined with computer graphics and robotics, physics, mathematics, and the arts.
Yang Yu   +4 more
doaj   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

Current trends in the physics of nanoscale friction

open access: yesAdvances in Physics: X, 2017
Tribology, which studies surfaces in contact and relative motion, includes friction, wear, and lubrication, straddling across different fields: mechanical engineering, materials science, chemistry, nanoscience, and physics. This short review restricts to
N. Manini   +4 more
doaj   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

From Galilean Relativity to Quantum Gravity : Three Issues, c, h, G, concerning Time, Matter and Inertia

open access: yes, 2011
An odd look at "standard" physics (Galileo, Newton, Einstein, Dirac) leading to a radical change of our concept of inertial motion and to new heuristic approaches of gravitation and the cosmological ...
Provost, Jean-Pierre
core   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

On Classical Motion [PDF]

open access: yes, 2018
The impetus theory of motion states that to be in motion is to have a non-zero velocity. The at-at theory of motion states that to be in motion is to be at different places at different times, which in classical physics is naturally understood as the ...
McCoy, C. D.
core   +2 more sources

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