Results 51 to 60 of about 2,227,329 (341)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Journal Of Babylon Center For Humanities Studies, 2021 The motivation to say poetry among the poets is variable and not fixed, according to the poet’s psychological state, fluctuations and poetic moment, and according to the poet’s environment and way of life, and the life situations that he faces in which ...
انعام حميد ناصر Inaam Hameed Naser +1 more
doaj
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Social and Religious Factors in Pilgrimages on the Way of Saint James
Quaestiones GeographicaeThis study examines the evolution of the Camino de Santiago into a hybrid of religious pilgrimage and spiritual tourism. Through statistical analysis and interviews with members of the Camino de Santiago Polska Facebook group, the research provides ...
OMELAN ANETA ANNA +2 more
doaj +1 more source
A Theoretical and Empirical Analysis of Challenges and motivations of Interdisciplinary Studies Implying on Interdisciplinary Methodology [PDF]
Interdisciplinary Studies in the Humanities, 2011 Purpose, although literature has focused on explaining theoretical background in the area of interdisciplinary studies, a few empirical studies has paid attention to the main reasons of performing interdisciplinary projects.
Mahdi Fatehrad +2 more
doaj +1 more source
Factors Influencing Household Solar Adoption in Santiago, Chile
, 2018 In Santiago, Chile, the market conditions are seemingly excellent for the household adoption of photovoltaic (PV) technology, yet the uptake is negligible.
Huepe, Claudio +2 more
core +1 more source
What personal and environmental factors determine frequency of urban greenspace use? [PDF]
, 2014 For many people, urban greenspaces are the only places where they encounter the natural world. This is concerning as there is growing evidence demonstrating that human well-being is enhanced by exposure to nature.
Altman +14 more
core +3 more sources
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Segmentation of rural tourists: combining push and pull motivations
Tourism and Hospitality Management, 2012 Rural tourism is an important form of tourism in many countries, including Finland. To understand rural tourists’ behaviour and help tourism companies market their products more efficiently many scholars have segmented rural tourists in several different
Juho A. Pesonen
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source