Results 121 to 130 of about 281,251 (358)
“Hide Our Heads in the Sand”: Environmental information avoidance motives in the United States
Frontiers in CommunicationInformation avoidance (IA) is a prevalent information behavior that is used by people to understand and act on environmental issues, yet is understudied in the environmental field, leaving us with an incomplete picture of environmental communication ...
Mary Beth Deline +3 more
doaj +1 more source
Mixed motives and motivic birational covers
Journal of Pure and Applied Algebra, 2017 18 pages; exposition simplified, removed unnecessary condition in former proposition 6.1 ...
openaire +2 more sources
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Dark motives-counterfeit selling framework
, 2018 Purpose – The purpose of this paper is to explore the motives of online sellers of counterfeit products in online social networking sites. Design/methodology/approach – The study uses a sample of 22 in-depth interviews with counterfeit sellers ...
Thaichon, Park +3 more
core +1 more source
STUDY OF EMOTIONAL MATURITY OF UNIVERSITY TEACHERS FROM THE POINT SYSTEMS APPROACH
Вестник Мининского университета, 2017 The article analyzes the phenomenon of emotional maturity from the perspective of various philosophical and psychological approaches (psychoanalytic, existential, humanistic, cognitive, emotional, cultural and historical).
L. V. Tarabakina, T. L. Shabanova
doaj
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source