Results 71 to 80 of about 213,335 (302)

Transcranial ultrasound stimulation of the human motor cortex

iScience, 2021
Summary: It has been 40 years since the report of long-term synaptic plasticity on the rodent brain. Transcranial ultrasound stimulation (TUS) shows advantages in spatial resolution and penetration depth when compared with electrical or magnetic ...
Yi Zhang, Liyuan Ren, Kai Liu, Shanbao Tong, Ti-Fei Yuan, Junfeng Sun   +5 more
doaj   +1 more source

Theta synchronization over occipito‐temporal cortices during visual perception of body parts [PDF]

, 2018
Categorical clustering in the visual system is thought to have evolved as a function of intrinsic (intra-areal) and extrinsic (interareal) connectivity and experience.
Aglioti, S, Candidi, M., Moreau, Q., Pavone, E.   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effects of acute fatigue on the volitional and magnetically-evoked electromechanical delay of the knee flexors in males and females [PDF]

, 2007
Neuromuscular performance capabilities, including those measured by evoked responses, may be adversely affected by fatigue; however, the capability of the neuromuscular system to initiate muscle force rapidly under these circumstances is yet to be ...
AJ McComas, AYF Chan, BD Beynnon, BR Mandelbaum, C Minshull, Claire Minshull, D Chu, David Rees, DE Rassier, E Arendt, EM Wojtys, FH Fu, H Johansson, I Tsuji, I Vivodtzev, J Gray, JT Hopkins, K Sahlin, LJ Huston, M Solomonow, M Solomonow, MA Moore, MI Polkey, Michelle Walters-Edwards, MJ Ireland, ML Latash, Nigel Gleeson, NP Gleeson, NP Gleeson, NP Gleeson, P Sbriccoli, PR Cavanagh, PV Komi, RM Norman, Roger Eston, S Zhou, S Zhou, S Zhou, S Zhou, SJ Shultz, T Horita, TH Mercer, V Strojnik   +42 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Comparison of two combinations of anaesthetic agents with and without ketamine for motor evoked potential during spine surgeries

The Indian Anaesthetists' Forum, 2017
Background: Anesthetic agents cause a dose-dependent effect on motor-evoked potentials (MEPs). We conducted a study to find whether addition of ketamine to the combination of propofol–fentanyl–dexmedetomidine has an effect on MEP monitoring and ...
Parashuram Chauhan, Deepika Aggarwal, Hari Kishan Mahajan, Ravinder Dhanerwa   +3 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Electrophysiological Guidance of Epidural Electrode Array Implantation over the Human Lumbosacral Spinal Cord to Enable Motor Function after Chronic Paralysis. [PDF]

, 2019
Epidural electrical stimulation (EES) of the spinal cord has been shown to restore function after spinal cord injury (SCI). Characterization of EES-evoked motor responses has provided a basic understanding of spinal sensorimotor network activity related ...
Beck, Lisa A, Brown, Desmond A, Calvert, Jonathan S, Edgerton, V Reggie, Gerasimenko, Yury P, Gill, Megan L, Grahn, Peter J, Lavrov, Igor A, Lee, Kendall H, Linde, Margaux B, Lopez, Cesar, Sayenko, Dimitry G, Strommen, Jeffrey A, Van Straaten, Meegan G, Veith, Daniel D, Zhao, Kristin D   +15 more
core  

Phase of beta-frequency tACS over primary motor cortex modulates corticospinal excitability

, 2018
The assessment of corticospinal excitability by means of transcranial magnetic stimulation-induced motor evoked potentials is an established diagnostic tool in neurophysiology and a widely used procedure in fundamental brain research.
De Gelder, B., De Graaf, T., Engelen, T., Sack, A., Schilberg, L., Schuhmann, T., Ten Oever, S.   +6 more
core   +1 more source