Results 71 to 80 of about 1,843,968 (305)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Detailed statement of motor vehicle registrations (in units)
, 2001 Annual; Description based on: 2000; title from caption (viewed Aug.
core
Variation in motor output and motor performance in a centrally generated motor pattern
Journal of Neurophysiology, 2014 Central pattern generators (CPGs) produce motor patterns that ultimately drive motor outputs. We studied how functional motor performance is achieved, specifically, whether the variation seen in motor patterns is reflected in motor performance and whether fictive motor patterns differ from those in vivo.
Angela, Wenning +3 more
openaire +3 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Summary statement of motor vehicle registrations (in dollars)
, 2004 Annual; Description based on: 2000; title from caption (viewed Aug.
core
MetalsThis study explores the application of AncorLam HR (Höganäs, Sweden), a soft magnetic composite material, in the stator core of an axial flux permanent magnet drive motor.
Seongsu Kang, Seonbong Lee
doaj +1 more source
G3: Genes, Genomes, Genetics, 2016 Drosophila larval crawling is an attractive system to study rhythmic motor output at the level of animal behavior. Larval crawling consists of waves of muscle contractions generating forward or reverse locomotion.
Matt Q. Clark +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source