Results 131 to 140 of about 495,385 (306)

Relation of Dominant Leg Use with Functional Symmetries in Young Football Players of Different Age Groups

open access: yesApplied Sciences
The aim of the study was to determine whether football players of different age groups who use their dominant leg more frequently when playing football exhibit greater functional asymmetries between the right and left leg. The study included 116 football
Matjaž Železnik   +2 more
doaj   +1 more source

Motor abilities of children of prepubescent age [PDF]

open access: yesFizička Kultura, 2019
Motor status is an important predictor of physical activity participation among prepubescent aged children. The aim of the present study was to present gender differences in the level of motor abilities among children of prepubescent age.
Milošević Živan N.
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

The Fine Motor Skills and Cognition Test Batteries: Normative Data and Interdependencies [PDF]

open access: yes
Fine motor skills and cognitive abilities are major contributors to crew performance on essentially all extravehicular and intra-vehicular activities during spaceflight.
Ahumada, Albert J., Jr.   +2 more
core   +1 more source

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