E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Comparative analysis of cardiorespiratory fitness, bio-motor abilities, and body composition indicators among sprint kayakers of different age groups and expertise levels. [PDF]
Front Physiol, 2023 Wang X, Zhao L.
europepmc +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Effect of interval and continuous small-sided games training on the bio-motor abilities of young soccer players: a comparative study. [PDF]
BMC Sports Sci Med Rehabil, 2023 Daryanoosh F +11 more
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Intelligent wearable allows out-of-the-lab tracking of developing motor abilities in infants. [PDF]
Commun Med (Lond), 2022 Airaksinen M +8 more
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
The Importance of Posture and Body Composition for The Stability and Selected Motor Abilities of Professional Handball Players. [PDF]
J Hum Kinet, 2022 Wilczyński J +3 more
europepmc +1 more source
The effect of motor abilities on karate performance.
Collegium antropologicum, 2006 The aim of the study was to identify the motor structures that determine achievement of top results in karate. The study included a sample of 85 karateka aged 18-29 years, competing as senior category athletes of the Croatian Karate Society. Fourteen motor tests (9 basic motor tests and 5 specific motor tests) were used to assess technical efficiency ...
Blažević, Stipe +2 more
openaire +3 more sources