Results 141 to 150 of about 495,385 (306)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Assessment of Motor Abilities and Physical Fitness in Youth in the Context of Talent Identification-OSF Test. [PDF]

Int J Environ Res Public Health, 2022
Baj-Korpak J, Stelmach MJ, Zaworski K, Lichograj P, Wochna M.   +4 more
europepmc   +1 more source

Relation between Motoric Abilities and Specific Motoric Abilities with Football Players from 14 to 16 Years Old

SSRN Electronic Journal
Football is one of the most famous games that man has invented. It is a complex of collective organization and individual ingenuity. No doubt, top results in sport require a serious base of scientific researches and skills. Certainly, modern top results that have been achieved can be analyzed scientifically.
Rabit Veseli, Musa Selimi, Arianit Morina, Nazim Myrtaj, Afrim Selimi   +4 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Caregiver-reported newborn term and preterm motor abilities: psychometrics of the PediaTrac^TM Motor domain. [PDF]

Pediatr Res, 2023
Lajiness-O'Neill R, Raghunathan T, Berglund P, Huth-Bocks A, Taylor HG, Staples AD, Brooks J, Lukomski A, Gidley Larson JC, Warschausky S, PediaTrac Project Consortium.   +10 more
europepmc   +1 more source

How nouns and verbs differentially affect the behavior of artificial organisms [PDF]

, 2001
This paper presents an Artificial Life and Neural Network (ALNN) model for the evolution of syntax. The simulation methodology provides a unifying approach for the study of the evolution of language and its interaction with other behavioral and neural ...
Cangelosi, Angelo, Parisi, Domenico
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Relationship between Body Composition and Specific Motor Abilities According to Position in Elite Female Soccer Players. [PDF]

Int J Environ Res Public Health, 2023
Stanković M, Čaprić I, Đorđević D, Đorđević S, Preljević A, Koničanin A, Maljanović D, Nailović H, Muković I, Jelaska I, Sporiš G.   +10 more
europepmc   +1 more source