Results 181 to 190 of about 605,394 (268)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Assessment of upper GI motor activity and GI symptoms in patients with amyotrophic lateral sclerosis: an observational study. [PDF]

Front Neurol
Ribichini E, Pallotta N, Badiali D, Carlucci M, Ceccanti M, Cambieri C, Libonati L, Corazziari ES, Ruoppolo G, Inghilleri M.   +9 more
europepmc   +1 more source

Sleep Bruxism Contributes to Motor Activity Increase during Sleep in Apneic and Nonapneic Patients-A Polysomnographic Study. [PDF]

Biomedicines, 2022
Wieczorek T, Michałek-Zrąbkowska M, Więckiewicz M, Mazur G, Rymaszewska J, Smardz J, Wojakowska A, Martynowicz H.   +7 more
europepmc   +1 more source

Feature Extraction for EEG Activity during 4 Limbs Motor Imagery in Time Domain

, 2018
Kenji Hontani, Ryosuke Shibata, Makoto Maeda, Katsuhiro Inoue   +3 more
openalex   +2 more sources

Daytime activity and sleep are associated with motor function in older intensive care unit survivors

, 2021
Maya Elias, Cindy L. Munro, Zhan Liang
openalex   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A novel ADP-directed chaperone function facilitates the ATP-driven motor activity of SARS-CoV helicase. [PDF]

Nucleic Acids Res
Yu J, Im H, Cho H, Jeon Y, Lee JB, Lee G.   +5 more
europepmc   +1 more source

Cortico-cortical activity between the primary and supplementary motor cortex: An intraoperative near-infrared spectroscopy study

, 2015
Masafumi Fukuda, Tetsuro Takao, Tetsuya Hiraishi, Hiroshi Aoki, Ryosuke Ogura, Yosuke Sato, Yukihiko Fujii   +6 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Influence of native thin filament type on the regulation of atrial and ventricular myosin motor activity. [PDF]

J Biol Chem
Spahiu E, Uta P, Kraft T, Nayak A, Amrute-Nayak M.   +4 more
europepmc   +1 more source