Results 41 to 50 of about 289,368 (258)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Low-Intensity Transcranial Ultrasound Stimulation Modulates the Excitability of Motor Cortical Neural Activity by Stimulating the Cerebellum

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Functional connectivity between the cerebellum and the motor cortex is critical for motor function. Low-intensity transcranial ultrasound stimulation (TUS) has been proved to directly activate cerebellar neural activity.
Huifang Yang, Zhe Zhao, Renhao Xu, Jiamin Pei, Jiaqing Yan, Xiangjian Zhang, Hanna Lu, Yi Yuan   +7 more
doaj   +1 more source

Corticospinal Circuits from the Sensory and Motor Cortices Differentially Regulate Skilled Movements through Distinct Spinal Interneurons

Cell Reports, 2018
Summary: Little is known about the organizational and functional connectivity of the corticospinal (CS) circuits that are essential for voluntary movement.
Masaki Ueno, Yuka Nakamura, Jie Li, Zirong Gu, Jesse Niehaus, Mari Maezawa, Steven A. Crone, Martyn Goulding, Mark L. Baccei, Yutaka Yoshida   +9 more
doaj   +1 more source

A robust role for motor cortex

Frontiers in Neuroscience, 2023
The role of motor cortex in non-primate mammals remains unclear. More than a century of stimulation, anatomical and electrophysiological studies has implicated neural activity in this region with all kinds of movement.
Gonçalo Lopes, Gonçalo Lopes, Gonçalo Lopes, Joana Nogueira, Joana Nogueira, Joana Nogueira, George Dimitriadis, George Dimitriadis, Jorge Aurelio Menendez, Jorge Aurelio Menendez, Jorge Aurelio Menendez, Joseph J. Paton, Adam R. Kampff, Adam R. Kampff, Adam R. Kampff   +14 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A longitudinal study of hand motor recovery after sub-acute stroke: a study combined FMRI with diffusion tensor imaging. [PDF]

PLoS ONE, 2013
Previous studies have shown that motor recovery of stroke can be assessed by the cortical activity and the structural integrity of the corticospinal tract (CST), but little is known about the relation between the cortical activity and the structural ...
Wenjuan Wei, Lijun Bai, Jun Wang, Ruwei Dai, Raymond Kai-yu Tong, Yumei Zhang, Zheng Song, Wen Jiang, Chuanying Shi, Mengyuan Li, Lin Ai, Jie Tian   +11 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Neural population dynamics in human motor cortex during movements in people with ALS

eLife, 2015
The prevailing view of motor cortex holds that motor cortical neural activity represents muscle or movement parameters. However, recent studies in non-human primates have shown that neural activity does not simply represent muscle or movement parameters;
Chethan Pandarinath, Vikash Gilja, Christine H Blabe, Paul Nuyujukian, Anish A Sarma, Brittany L Sorice, Emad N Eskandar, Leigh R Hochberg, Jaimie M Henderson, Krishna V Shenoy   +9 more
doaj   +1 more source

Isolated shoulder weakness as a result of a cortical infarction in the precentral gyrus [PDF]

Journal of Community Hospital Internal Medicine Perspectives, 2015
Since its discovery, our understanding of the primary motor cortex has continued to evolve. The presentations of rare, isolated, motor palsies of small muscle groups have heavily contributed to the characterization of the somatotopic representation of ...
Pouya Entezami, John A. Hopper
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source