Results 51 to 60 of about 1,651,137 (254)

Low-Intensity Transcranial Ultrasound Stimulation Modulates the Excitability of Motor Cortical Neural Activity by Stimulating the Cerebellum

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Functional connectivity between the cerebellum and the motor cortex is critical for motor function. Low-intensity transcranial ultrasound stimulation (TUS) has been proved to directly activate cerebellar neural activity.
Huifang Yang, Zhe Zhao, Renhao Xu, Jiamin Pei, Jiaqing Yan, Xiangjian Zhang, Hanna Lu, Yi Yuan   +7 more
doaj   +1 more source

Corticospinal Circuits from the Sensory and Motor Cortices Differentially Regulate Skilled Movements through Distinct Spinal Interneurons

Cell Reports, 2018
Summary: Little is known about the organizational and functional connectivity of the corticospinal (CS) circuits that are essential for voluntary movement.
Masaki Ueno, Yuka Nakamura, Jie Li, Zirong Gu, Jesse Niehaus, Mari Maezawa, Steven A. Crone, Martyn Goulding, Mark L. Baccei, Yutaka Yoshida   +9 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Point-light biological motion perception activates human premotor cortex [PDF]

, 2004
Motion cues can be surprisingly powerful in defining objects and events. Specifically, a handful of point-lights attached to the joints of a human actor will evoke a vivid percept of action when the body is in motion.
Hagler, DJ, Saygin, Ayse Pinar, Bates, Elizabeth, Sereno, MI, Hagler, Donald J, Saygin, AP, Wilson, SM, Bates, E, Wilson, Stephen M, Sereno, Martin I   +9 more
core  

A longitudinal study of hand motor recovery after sub-acute stroke: a study combined FMRI with diffusion tensor imaging. [PDF]

PLoS ONE, 2013
Previous studies have shown that motor recovery of stroke can be assessed by the cortical activity and the structural integrity of the corticospinal tract (CST), but little is known about the relation between the cortical activity and the structural ...
Wenjuan Wei, Lijun Bai, Jun Wang, Ruwei Dai, Raymond Kai-yu Tong, Yumei Zhang, Zheng Song, Wen Jiang, Chuanying Shi, Mengyuan Li, Lin Ai, Jie Tian   +11 more
doaj   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Suppressing Systemic Interference in fNIRS Monitoring of the Hemodynamic Cortical Response to Motor Execution and Imagery

Frontiers in Human Neuroscience, 2018
Hemodynamic response to motor execution (ME) and motor imagery (MI) was investigated using functional near-infrared spectroscopy (fNIRS). We used a 31 channel fNIRS system which allows non-invasive monitoring of cerebral oxygenation changes induced by ...
Shijing Wu, Shijing Wu, Jun Li, Lantian Gao, Changshui Chen, Sailing He   +5 more
doaj   +1 more source

Isolated shoulder weakness as a result of a cortical infarction in the precentral gyrus [PDF]

Journal of Community Hospital Internal Medicine Perspectives, 2015
Since its discovery, our understanding of the primary motor cortex has continued to evolve. The presentations of rare, isolated, motor palsies of small muscle groups have heavily contributed to the characterization of the somatotopic representation of ...
Pouya Entezami, John A. Hopper
doaj   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Neural population dynamics in human motor cortex during movements in people with ALS

eLife, 2015
The prevailing view of motor cortex holds that motor cortical neural activity represents muscle or movement parameters. However, recent studies in non-human primates have shown that neural activity does not simply represent muscle or movement parameters;
Chethan Pandarinath, Vikash Gilja, Christine H Blabe, Paul Nuyujukian, Anish A Sarma, Brittany L Sorice, Emad N Eskandar, Leigh R Hochberg, Jaimie M Henderson, Krishna V Shenoy   +9 more
doaj   +1 more source