Results 61 to 70 of about 561,492 (257)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Frontiers in Human Neuroscience, 2018 Hemodynamic response to motor execution (ME) and motor imagery (MI) was investigated using functional near-infrared spectroscopy (fNIRS). We used a 31 channel fNIRS system which allows non-invasive monitoring of cerebral oxygenation changes induced by ...
Shijing Wu +5 more
doaj +1 more source
Motor deficits are produced by removing some cortical transplants grafted into injured sensorimotor cortex of neonatal rats. [PDF]
, 1991 Fetal frontal cortex was transplanted into cavities formed in the right motor cortex of neonatal rats. As adults, the animals were trained to press two levers in rapid succession with their left forelimb to receive food rewards.
Gonzalez, MF +3 more
core
Anomalous morphology in left hemisphere motor and premotor cortex of children who stutter [PDF]
, 2018 Stuttering is a neurodevelopmental disorder that affects the smooth flow of speech production. Stuttering onset occurs during a dynamic period of development when children first start learning to formulate sentences.
Chang, Soo-Eun +5 more
core +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Hand Motor Cortex Excitability During Speaking in Persistent Developmental Stuttering
Frontiers in Human Neuroscience, 2019 Persistent developmental stuttering (PDS) is a speech fluency disorder characterized by intermittent involuntary breakdowns of speech motor control, possibly related to motor cortex excitability.
Martin Sommer +3 more
doaj +1 more source
Task-free functional MRI in cervical dystonia reveals multi-network changes that partially normalize with botulinum toxin. [PDF]
PLoS ONE, 2013 Cervical dystonia is characterized by involuntary, abnormal movements and postures of the head and neck. Current views on its pathophysiology, such as faulty sensorimotor integration and impaired motor planning, are largely based on studies of focal hand
Cathérine C S Delnooz +3 more
doaj +1 more source
Complex-Valued Time-Series Correlation Increases Sensitivity in FMRI Analysis [PDF]
, 2016 Purpose To develop a linear matrix representation of correlation between complex-valued (CV) time-series in the temporal Fourier frequency domain, and demonstrate its increased sensitivity over correlation between magnitude-only (MO) time-series in ...
Kociuba, Mary C., Rowe, Daniel B.
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela +13 more
wiley +1 more source
Neural population dynamics in human motor cortex during movements in people with ALS
eLife, 2015 The prevailing view of motor cortex holds that motor cortical neural activity represents muscle or movement parameters. However, recent studies in non-human primates have shown that neural activity does not simply represent muscle or movement parameters;
Chethan Pandarinath +9 more
doaj +1 more source