Results 31 to 40 of about 253,081 (215)

Perceptual Motor Skills in Children and Pupils with Mild Intellectual Disabilities

Multidisciplinary Journal of School Education, 2020
This literature review analyzes eight specialized papers which focus on issues of the perceptual motor skills of children and pupils with mild intellectual disabilities. Children and pupils with mild intellectual disabilities have deficits in perceptual
Jan Viktorin, Lucie Loosová
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Effects of a single mental chronometry training session in subacute stroke patients – a randomized controlled trial

BMC Sports Science, Medicine and Rehabilitation, 2020
Background Motor imagery training might be helpful in stroke rehabilitation. This study explored if a single session of motor imagery (MI) training induces performance changes in mental chronometry (MC), motor execution, or changes of motor excitability.
Joachim Liepert, Jana Stürner, Imke Büsching, Aida Sehle, Mircea A. Schoenfeld   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mild Concussion, but Not Moderate Traumatic Brain Injury, Is Associated with Long-Term Depression-Like Phenotype in Mice. [PDF]

PLoS ONE, 2016
Mild traumatic brain injuries can lead to long-lasting cognitive and motor deficits, increasing the risk of future behavioral, neurological, and affective disorders.
Nikita M Bajwa, Shina Halavi, Mary Hamer, Bridgette D Semple, Linda J Noble-Haeusslein, Mohsen Baghchechi, Alex Hiroto, Richard E Hartman, André Obenaus   +8 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Expanded Phenotype of the Cln6^nclf Mouse Model

Cells
Neuronal ceroid lipofuscinoses (NCLs) are a group of autosomal recessive neurogenetic disorders caused by mutations in 14 different genes. CLN6 disease manifests as variant late-infantile NCL (vLINCL) or as an adult variant.
Victoria Chaoul, Sara Saab, Omar Shmoury, Ramy Alam, Lynn Al Aridi, Nadine J. Makhoul, Jihane Soueid, Rose-Mary Boustany   +7 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Altered motor coordination, vocal communication, and cerebellar circuit connectivity in mice carrying a near-complete human chromosome 21

Translational Psychiatry
Individuals with Down syndrome (DS) frequently face challenges with motor control and coordination, affecting their daily physical movements. The neural mechanism underlying motor coordination deficits in DS remains poorly understood.
Rachel Stander, Nithilah Ayyappan, Darek Sikorski, Meike E. van der Heijden, Kuangfu Hsiao   +4 more
doaj   +1 more source

Focal Traumatic Brain Injury Impairs the Integrity of the Basement Membrane of Hindlimb Muscle Fibers Revealed by Extracellular Matrix Immunoreactivity

Life
Traumatic brain injury (TBI) stands as a prominent global cause of disability, with motor deficits being a common consequence. Despite its widespread impact, the precise pathological mechanisms underlying motor deficits after TBI remain elusive.
Mette Albæk Kristensen, Karen Kalhøj Rich, Tobias Christian Mogensen, Andreas Malmquist Damsgaard Jensen, Åsa Fex Svenningsen, Mengliang Zhang   +5 more
doaj   +1 more source