Results 51 to 60 of about 16,236,140 (303)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Optimizing Design Structure Matrices Using Markov Chain Modeling and Community Detection

IEEE Open Journal of Systems Engineering
This article proposes a new method to enhance the efficiency of the design process in systems engineering. Our approach involves utilizing a Markov chain based on the design structure matrix (DSM).
Rami Al Khatib, Armando Chacon
doaj   +1 more source

Parameterized Energy-Optimal Regenerative Braking Strategy for Connected and Autonomous Electrified Vehicles: A Real-Time Dynamic Programming Approach

IEEE Access, 2021
This paper presents a vehicle speed planning system called the energy-optimal deceleration planning system (EDPS), which aims to maximize energy recuperation of regenerative braking of connected and autonomous electrified vehicles.
Dohee Kim, Jeong Soo Eo, Kwang-Ki K. Kim
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Variational autoencoder-based techniques for a streamlined cross-topology modeling and optimization workflow in electrical drives

Autonomous Intelligent Systems
The generation and optimization of simulation data for electrical machines remain challenging, largely due to the complexities of magneto-static finite element analysis.
Marius Benkert, Michael Heroth, Rainer Herrler, Magda Gregorová, Helmut C. Schmid   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The effect of a selected training program under dual-task and single-task conditions on the cognitive flexibility of children with developmental coordination disability [PDF]

Ravānshināsī-i Afrād-i Istis̠nāyī, 2019
The purpose of this study was to investigate the effect of a selected training program under dual and single-task conditions on the cognitive flexibility of children with developmental coordination disorder.
Hamideh Jahanbakhsh, mehdi sohrabi, Alireza Saberi Kakhki, Ezzat khodashenas   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Evidence for Brainstem Contributions to Autism Spectrum Disorders

Frontiers in Integrative Neuroscience, 2018
Autism spectrum disorder (ASD) is a neurodevelopmental condition that affects one in 59 children in the United States. Although there is a mounting body of knowledge of cortical and cerebellar contributions to ASD, our knowledge about the early ...
Olga I. Dadalko, Brittany G. Travers
doaj   +1 more source