Results 71 to 80 of about 748,285 (303)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Does implicit motor learning lead to greater automatization of motor skills compared to explicit motor learning?: A systematic review [PDF]

, 2018
Background Implicit motor learning is considered to be particularly effective for learning sports-related motor skills. It should foster movement automaticity and thereby facilitate performance in multitasking and high-pressure environments.
Winters, M, Rens Prosée, Prosée, R, Marinus Winters, Van Der Kamp, John, Kal, Elmar, John van der Kamp, Winters, Marinus, Rens Prosée (5721362), Van Der Kamp, J, Elmar Kal (5721359), John van der Kamp (442853), Van Der Kamp, John; id_orcid, Prosée, Rens, Elmar Kal, Marinus Winters (5721365), Kal, E   +16 more
core   +1 more source

Data-Driven Driver Training via Counterfactual and Language-Based Guidance in Racing Scenarios

IEEE Access
Novice drivers in automobile racing face significant challenges in improving racing performance while maintaining safety. Traditional one-on-one human coaching faces practical limitations, such as subjectivity, inconsistency, high cost, and limited ...
Jonghak Bae, Hyeongwoo Nam, Kunhee Ryu, Jihye Lee, Jinsung Kim, Hokyun Chun, Jongtaek Han, Jongeun Choi   +7 more
doaj   +1 more source

Periodic mild heat stimuli diminish extracellular matrix synthesis in pellet cultured human chondrocytes

BMC Research Notes, 2019
Objective This study aimed to clarify the effects of periodic mild heat stimuli on extracellular matrix (ECM) synthesis of adult human chondrocytes in 3-dimensional pellet culture.
Akira Ito, Tomoki Aoyama, Hirotaka Iijima, Kohei Nishitani, Junichi Tajino, Hiroshi Kuroki   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A proposal for a comprehensive grading of Parkinson's disease severity combining motor and non-motor assessments: meeting an unmet need. [PDF]

, 2013
Non-motor symptoms are present in Parkinson's disease (PD) and a key determinant of quality of life. The Non-motor Symptoms Scale (NMSS) is a validated scale that allows quantifying frequency and severity (burden) of NMS.
Brown, Richard J., Jose Manuel Rojo (382888), Stocchi, Fabrizio, Chaudhuri, Kallol Ray, Martinez-Martin, Pablo, Richard J. Brown (382891), David J. Brooks (316043), Brooks, David J., Ray Chaudhuri, K, Antonini, A, Kallol Ray Chaudhuri, Stocchi, F, Schapira, Anthony H. V., Richard G Brown, Brooks, David J, Anthony H. V. Schapira (139480), Fabrizio Stocchi (382889), Odin, Per, Martinez-Martin, P, Rojo, JM, Schapira, AH, Anthony H V Schapira, Fabrizio Stocchi, Per Odin (382890), Antonini, Angelo, Odin, P, Brooks, DJ, Kallol Ray Chaudhuri (382887), David J Brooks, Pablo Martinez-Martin, Odin, Per,, Manuel Rojo, Jose, Ray Chaudhuri, Kallol, Brown, RJ, Rojo, Jose Manuel, Pablo Martinez-Martin (3179352), Schapira, Anthony H V, Brown, Richard J.; id_orcid, Jose Manuel Rojo, Per Odin, Angelo Antonini (222327), Lund University., Angelo Antonini   +42 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Do motor skills impact on language development in toddlers?

, 2019
Recent studies have shown that motor development and language development are more interrelated than it has previously been thought, mostly in the first years of life.
Rigo F., Lavelli M., Andalò B.
core  

Implicit motor learning promotes neural efficiency during laparoscopy. [PDF]

, 2011
An understanding of differences in expert and novice neural behavior can inform surgical skills training. Outside the surgical domain, electroencephalographic (EEG) coherence analyses have shown that during motor performance, experts display less ...
Maxwell, JP, Rich S. W. Masters, Frank F. Zhu, Masters, RS, Wilson, MR, Yong Hu, Jon P. Maxwell, Poolton, JM, Hu, Y, Zhu, FF, Jamie M. Poolton, Masters, RSW, Mark R. Wilson   +12 more
core   +1 more source