Results 71 to 80 of about 129,554 (354)

Voluntary activation of human knee extensors measured using transcranial magnetic stimulation [PDF]

, 2009
The aim of this study was to determine the applicability and reliability of a transcranial magnetic stimulation twitch interpolation technique for measuring voluntary activation of a lower limb muscle group.
Goodall, Stuart, Romer, Lee, Ross, Emma
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Evoked potentials as biomarkers of hereditary spastic paraplegias: A case-control study.

PLoS ONE, 2021
IntroductionThe Hereditary Spastic Paraplegias (HSP) are a group of genetic diseases that lead to slow deterioration of locomotion. Clinical scales seem to have low sensitivity in detecting disease progression, making the search for additional biomarkers
Samanta Ferraresi Brighente, Paul Vicuña, Ana Luiza Rodrigues Louzada, Gabriela Marchisio Giordani, Helena Fussiger, Marco Antonnio Rocha Dos Santos, Diana Maria Cubillos-Arcila, Pablo Brea Winckler, Jonas Alex Morales Saute   +8 more
doaj   +1 more source

Combining brain-computer interfaces and assistive technologies: state-of-the-art and challenges [PDF]

, 2010
In recent years, new research has brought the field of EEG-based Brain-Computer Interfacing (BCI) out of its infancy and into a phase of relative maturity through many demonstrated prototypes such as brain-controlled wheelchairs, keyboards, and computer ...
Cincott, F., del R. Millan, J., Giugliemma, C., Kubler, A., Leeb, R., Mattia, D., Muller, K.R., Muller-Putz, G., Murray-Smith, R., Neuper, C., Rupp, R., Tangermann, M., Vidaurre, C.   +12 more
core   +7 more sources

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Intraoperative response of the pyramidal system to surgical correction of spinal deformities of various etiologies

Хирургия позвоночника, 2019
Objective. To assess the information value of comparing the results of formalizing intraoperative changes in transcranial motor evoked potentials during surgical correction of spinal deformities of various etiologies. Material and Methods.
Marat S. Saifutdinov, Sergey O. Ryabykh, Dmitry M. Savin, Polina V. Ochirova, Egor Yu. Filatov   +4 more
doaj   +1 more source

Nociceptive-Evoked Potentials Are Sensitive to Behaviorally Relevant Stimulus Displacements in Egocentric Coordinates. [PDF]

, 2016
Feature selection has been extensively studied in the context of goal-directed behavior, where it is heavily driven by top-down factors. A more primitive version of this function is the detection of bottom-up changes in stimulus features in the ...
DI STEFANO, Giulia, Djeugam, B, Iannetti, Gd, Liang, M, Moayedi, M, Stubbs, Mt   +5 more
core   +3 more sources

Translating a Preclinically Tested 15 Hz rTMS Protocol to Humans With Chronic Spinal Cord Injury: A Safety and Feasibility Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Repetitive transcranial magnetic stimulation (rTMS) is a non‐invasive brain stimulation strategy with a demonstrated potential to reinforce the residual pathways after a spinal cord injury (SCI). A preclinically tested high‐frequency (15 Hz) rTMS (15 Hz rTMS) protocol was shown to induce corticospinal tract axon regeneration growth ...
Nabila Brihmat, Mehmed B. Bayram, Morgan Paine, Janelle Carnahan, Jian Zhong, Xiaofei Guan, Guang H. Yue, Soha Saleh, Gail F. Forrest   +8 more
wiley   +1 more source

Command Interneurons in the Crayfish Central Nervous System [PDF]

, 1967
The motor effects evoked by stimulation of each of eight command fibres in the circumoesophageal commissures of the crayfish are described. The fibres obtained appeared to have widespread connexions in all or most of the lower ganglia. For certain fibres
Atwood, H. L., Wiersma, C. A. G.
core