Results 101 to 110 of about 343,489 (291)

Cortical functioning in children with developmental coordination disorder:a motor overflow study [PDF]

, 2015
This study examined brain activation in children with developmental coordination disorder (DCD) to reveal areas that may contribute to poor movement execution and/or abundant motor overflow.
American Psychiatric Association, American Psychiatric Association, Anne M. Winsor, Ashleigh L. Thornton, B Elbasan, Catherine M. Elliott, D Dewey, Erin Robins, F Binkofski, F Binkofski, F Boisgueheneuc Du, G Venkatasubramanian, J Cairney, J Kuhtz-Buschbeck, J Zwicker, J Zwicker, Jac Billington, JG Zwicker, JM Werner, John P. Wann, JP Piek, L Querne, LK MacNeil, M Kashiwagi, M Licari, M Licari, M Ozbič, Melissa K. Licari, Michael Bynevelt, ML Wolraich, NC Andreasen, P Mariën, R Blank, Randall Jones, RC Oldfield, RH Largo, RH Largo, S Mouchet-Mages, SE Henderson, SH Mostofsky, Siobhan L. Reid, World Health Organisation   +41 more
core   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Decoding of four movement directions using hybrid NIRS-EEG brain-computer interface

Frontiers in Human Neuroscience, 2014
The hybrid brain-computer interface (BCI)’s multimodal technology enables precision brain-signal classification that can be used in the formulation of control commands.
M. Jawad Khan, Melissa Jiyoun Hong, Keum-Shik eHong   +2 more
doaj   +1 more source

The fourth dimension: A motoric perspective on the anxiety–performance relationship [PDF]

, 2015
This article focuses on raising concern that anxiety–performance relationship theory has insufficiently catered for motoric issues during, primarily, closed and self-paced skill execution (e.g., long jump and javelin throw). Following a review of current
Carson, H.J.,, Collins, D.
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Inferior frontal oscillations reveal visuo-motor matching for actions and speech: evidence from human intracranial recordings. [PDF]

, 2015
The neural correspondence between the systems responsible for the execution and recognition of actions has been suggested both in humans and non-human primates. Apart from being a key region of this visuo-motor observation-execution matching (OEM) system,
Blanke, O., Halje, P., Ionta, S., Seeck, M.   +3 more
core   +2 more sources

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Brain oxygenation patterns during the execution of tool use demonstration, tool use pantomime, and body-part-as-object tool use [PDF]

, 2015
© 2015 Elsevier B.V. Divergent findings exist whether left and right hemispheric pre- and postcentral cortices contribute to the production of tool use related hand movements. In order to clarify the neural substrates of tool use demonstrations with tool
Helmich, Ingo, Holle, Henning, Lausberg, Hedda, Rein, Robert   +3 more
core   +2 more sources

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source