Results 91 to 100 of about 85,282 (282)

Functional and structural connectivity between the cerebellum and the cortical mirror neuron system: evidence from fMRI and DTI probabilistic tractography

NeuroImage
Studies in humans and monkeys have shown that action observation activates not only cortical areas of the mirror neuron system (MNS) but also the cerebellum and other subcortical structures.
Antonino Errante, Eleonora Sicuri, Cristina Russo, Giuseppe Ciullo, Alessandro Piras, Marzio Gerbella, Leonardo Fogassi   +6 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Embodied Gesture Processing: Motor-based Perception-Action Integration in Social Artificial Agents

, 2010
Sadeghipour A, Kopp S. Embodied Gesture Processing: Motor-based Perception-Action Integration in Social Artificial Agents. Cognitive Computation. 2011;3(3):419-435.A close coupling of perception and action processes is assumed to play an important role ...
Kopp, Stefan ; https://orcid.org/, Amir Sadeghipour, Stefan Kopp, Sadeghipour, Amir   +3 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Dopamine inactivation efficacy related to functional DAT1 and COMT variants influences motor response evaluation [PDF]

, 2012
BACKGROUND: Dopamine plays an important role in orienting, response anticipation and movement evaluation. Thus, we examined the influence of functional variants related to dopamine inactivation in the dopamine transporter (DAT1) and catechol-O ...
Laucht, Manfred (Prof. Dr.), Rellum Thomas, Thomas Rellum, Resch, Franz, Stephan Bender, Brandeis, Daniel, Banaschewski, Tobias, Laucht Manfred, Bender, Stephan, Rietschel, Marcella, Jennen-Steinmetz, Christine, Freitag, Christine M., Treutlein, Jens, Jens Treutlein, Rellum, Thomas, Daniel Brandeis, Brandeis Daniel, Tobias Banaschewski, Jennen-Steinmetz Christine, Christine Freitag, Bender Stephan, Banaschewski Tobias, Manfred Laucht, Freitag, Christine, Franz Resch, Rietschel Marcella, Marcella Rietschel, Resch Franz, Christine Jennen-Steinmetz, Laucht, Manfred, Treutlein Jens, Freitag Christine   +31 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The role of mirror neurons in observational motor learning: an integrative review

European Journal of Human Movement, 2014
Mirror neurons were discovered in the early 1990’s in the premotor cortex of the rhesus macaque. These  special, visuo-motor neurons discharge action potentials when executing an action, as well as during the observation of the performance of a similar ...
Angel Lago-Rodríguez, Binith Cheeran, Giacomo Koch, Tibor Hortobagy, Miguel Fernandez-del-Olmo   +4 more
doaj  

The Effects of Action Observation Speed on Motor Function in Patients with Chronic Low Back Pain: From Observation to Execution [PDF]

Objective: The objective of this study was to examine the effect of observing actions at different speeds on the speed of motor task performance in subsequent actions.
Manuel Estradera-Bel, Forner Álvarez, Carlos, Celia Vidal-Quevedo, Ferran Cuenca-Martínez, Grande Alonso, Mónica, Carlos Forner-Álvarez, Vidal Quevedo, Celia, Mónica Grande-Alonso, Alba Paris-Alemany, Roy La Touche, Paris Alemany, Alba, La Touche, Roy, Estradera Bel, Manuel, Cuenca Martínez, Ferrán   +13 more
core   +1 more source

Functional interplay between posterior parietal and ipsilateral motor cortex revealed by twin-coil transcranial magnetic stimulation during reach planning toward contralateral space

, 2008
Posterior parietal cortex (PPC) has connections with motor and premotor cortex, thought to transfer information relevant for planning movements in space.
Del Olmo, MF, Caltagirone, C., Del Olmo, M. F., Driver, J., Koch, G, Cheeran, B., Rothwell, J. C., Koch, G., Schippling, S, Driver, J, Rothwell, J, Cheeran, Binith, Schippling, S., Caltagirone, C, Cheeran, B, Rothwell, JC, Fernandez Del Olmo, M   +16 more
core   +1 more source

Multiple roles of motor imagery during action observation [PDF]

, 2013
Over the last 20 years, the topics of action observation (AO) and motor imagery (MI) have been largely studied in isolation from each other, despite the early integrative account by Jeannerod (1994, 2001). Recent neuroimaging studies demonstrate enhanced
Stefan eVogt, Aymeric eGuillot, Collins, Alan, Di Rienzo, Franck, Vogt, Stefan, Guillot, Aymeric, Allan eCollins, Franck eDi Rienzo, Collet, Christian, Christian eCollet   +9 more
core   +1 more source