Results 81 to 90 of about 85,282 (282)

Impairment of gradual muscle adjustment during wrist circumduction in Parkinson's disease [PDF]

, 2011
Purposeful movements are attained by gradually adjusted activity of opposite muscles, or synergists. This requires a motor system that adequately modulates initiation and inhibition of movement and selectively activates the appropriate muscles.
van der Hoeven Johannes H., Leenders Klaus L., Valsan, Gopal, de Jong, Bauke M.; id_orcid, Toxopeus Carolien M., Klaus L. Leenders, Carolien M. Toxopeus, Bauke M. de Jong, Natasha M. Maurits, Bernard A. Conway, Leenders, Klaus L., Gopal Valsan, Bernard A Conway, Johannes H van der Hoeven, Klaus L Leenders, Maurits, Natasha M.; id_orcid, de Jong, Bauke M., Conway Bernard A., Johannes H. van der Hoeven, Maurits, Natasha M., Conway, Bernard A., Carolien M Toxopeus, Natasha M Maurits, Maurits Natasha M., Toxopeus, Carolien M., Valsan Gopal, Bauke M de Jong, van der Hoeven, Johannes H., de Jong Bauke M.   +28 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Changes in spinal motoneuron excitability during the improvement of fingertip dexterity by actual execution combined with motor imagery practice

Heliyon
Since there is an upper limit to skill improvement through the repetition of actual execution, we examined whether motor imagery could be used in combination with actual execution to maximize motor skill improvement.
Yuki Fukumoto, Marina Todo, Makoto Suzuki, Daisuke Kimura, Toshiaki Suzuki   +4 more
doaj   +1 more source

Children with cerebral palsy have altered oscillatory activity in the motor and visual cortices during a knee motor task

NeuroImage: Clinical, 2017
The neuroimaging literature on cerebral palsy (CP) has predominantly focused on identifying structural aberrations within the white matter (e.g., fiber track integrity), with very few studies examining neural activity within the key networks that serve ...
Max J. Kurz, Amy L. Proskovec, James E. Gehringer, Elizabeth Heinrichs-Graham, Tony W. Wilson   +4 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Fine Modulation in Network Activation during Motor Execution and Motor Imagery [PDF]

Cerebral Cortex, 2004
Motor imagery, the 'mental rehearsal of motor acts without overt movements', involves either a visual representation (visual imagery, VI) or mental simulation of movement, associated with a kinesthetic feeling (kinetic imagery, KI). Previous brain imaging work suggests that patterns of brain activation differ when comparing execution (E) with either ...
Ana, Solodkin, Petr, Hlustik, E Elinor, Chen, Steven L, Small   +3 more
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

An Efficient Deep Transfer Learning Network for Characterization of Stroke Patients’ Motor Execution from Multi-Channel EEG-Recordings [PDF]

Recent advances in stroke rehabilitation technology have been focused on developing Intelligent Rehabilitation Robots (IRR) that can effectively engage post-stroke patients (PSP) in intuitive motor training for full function recovery.
Aboyeji, S. T., Samuel, O., Kulwa, F., McEwan, A., Khushaba, R., Asogbon, M.   +5 more
core   +1 more source

Executive Functioning, Motor Difficulties, and Developmental Coordination Disorder [PDF]

Developmental Neuropsychology, 2015
The current study assessed a comprehensive range of executive functions (EFs) in children with poor motor skills, comparing profiles of children with a diagnosis of developmental coordination disorder (DCD) and those identified with motor difficulties (MD).
Leonard, H.C., Bernardi, M., Hill, E. L., Henry, L.   +3 more
openaire   +5 more sources