Results 51 to 60 of about 7,414,218 (263)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Motor learning and neuroplasticity in humans [PDF]

, 2009
The central nervous system is plastic, in that the number and strength of synaptic connections changes over time. In the adult the most important driver of such changes is experience, in the form of learning and memory. There are thought to be a number
Teo, J.T.H., Teo, J T H
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Is Implicit Motor Learning Preserved after Stroke? A Systematic Review with Meta-Analysis [PDF]

, 2016
Many stroke patients experience difficulty with performing dual-tasks. A promising intervention to target this issue is implicit motor learning, as it should enhance patients' automaticity of movement.
Scherder, E., Houdijk, H, Scherder E., Scherder, E.J.A., Winters, M, Kal, E.C., Kal, E., Groet, E., Groet, E, van der Kamp, J, van Bennekom, C., Scherder, E, Bennekom, C, van der Kamp, J., Winters M., Kal, E, Houdijk, H., Van Kamp, JD, Houdijk, Han, J. van der Kamp (789546), van Bennekom C., E. Kal (3589775), E. Groet (789548), Winters, M., Kal E., van der Kamp, J; id_orcid, M. Winters (3589769), Houdijk H., H. Houdijk (789547), van der Kamp J., C. van Bennekom (3589772), E. Scherder (3589766), Groet E.   +32 more
core   +1 more source

Sustainability of a Given Ten-Week Motor Skills Training Program for Children with Developmental Coordination Disorder

Sports, 2022
The aim of this research was to determine the sustainability of a given ten-week motor skills training program for children with developmental coordination disorder (DCD).
Orifjon Saidmamatov, Ko’palov Sanjarbek, Olga Vasconcelos, Paula Rodrigues   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Challenging ideals of connected learning: the networked configurations for learning of migrant youth in the Netherlands [PDF]

, 2014
New infrastructures that dramatically change our possibilities for knowledge production and learning have also brought forward ideals on ‘new’ connectivity.
Ünlüsoy, Asli, Prinsen, Fleur, Leander, Kevin, Leerstoel Leseman, de Haan, Mariette, Education and Learning: Cognitive and Motor Disabilities   +5 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Self-perceptions and physical activity in children with and without motor problems [PDF]

, 2017
Self-perceptions influence global self-esteem and intrinsic motivation for achievement behavior (e.g., physical activity). Physical activity is an important component of a healthy lifestyle.
Noordstar, J.J., Leerstoel Jongmans, Education and Learning: Cognitive and Motor Disabilities   +2 more
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