Results 81 to 90 of about 7,875,577 (252)

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A psycholinguistic exploration of focus of attention in second language learning based on recent research findings from the field of motor skill learning [PDF]

, 2009
Significant findings from motor skill learning research provide evidence that focus of attention (FOA), induced through instruction, impacts on performance and learning (Wulf, 2007). External FOA instructions, which direct focus to the effect of actions,
Kelly-Coll, Clare
core   +2 more sources

Retraining-Efficiency Score (RES): A Simple, Cost-Aware Promotion Rule for Green and Accurate Forecasting

IEEE Access
Deployed machine-learning models deteriorate as data, user behavior, and context drift. Fixed retraining schedules therefore waste operational resources and deployment bandwidth when drift is mild, yet allow avoidable error spikes when drift is severe ...
Jayachander Reddy Kandakatla
doaj   +1 more source

Task-Specific Training, Learning, and Memory for Children with Developmental Coordination Disorder: A Pilot Study

, 2008
Summary.—This pilot study compared learning and memory profiles of 20 children (55% boys; M age= 7.3 yr, SD=0.4) identified as having learning difficulties as well as either having or suspected of having Developmental Coordination Disorder.
Claire Warner, Alloway, Tracy Packiam, Warner, Claire, Tracy Packiam Alloway   +3 more
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

The Effect of 8 Weeks Aerobic Training on the Social Adjustment in Mentally Retarded Children with Hemiplegic Cerebral Palsy

Annals of Applied Sport Science, 2015
One of the most important and basic problems in mentally retarded children which can form the basis of their behavior is impairment in social adjustment and performance.
Zahra Pooraghaei Ardakani, Forough Rahmati   +1 more
doaj  

Coupling Robot-Aided Assessment and Surface Electromyography (sEMG) to Evaluate the Effect of Muscle Fatigue on Wrist Position Sense in the Flexion-Extension Plane

Frontiers in Human Neuroscience, 2019
Proprioception is a crucial sensory modality involved in the control and regulation of coordinated movements and in motor learning. However, the extent to which proprioceptive acuity is influenced by local muscle fatigue is obscured by methodological ...
Maddalena Mugnosso, Maddalena Mugnosso, Jacopo Zenzeri, Charmayne M. L. Hughes, Francesca Marini   +4 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source