Results 221 to 230 of about 8,574,707 (338)

Structure-function association of the cerebellar motor network is altered in isolated cervical dystonia. [PDF]

J Neurol
Grimm K, Braaß H, Sadeghi F, Gelderblom M, Schulz R, Zittel S.   +5 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Motor network pre-habilitation by low-frequency repetitive transcranial magnetic stimulation. A proof-of-concept. [PDF]

Acta Neurochir (Wien)
Ben Dor N, Raffa G, Scibilia A, Espahbodinea S, Garcia C, La Torre D, Ziv G, Friso F, Granata F, Vinci S, Rustici A, Cardali SM, Garufi G, Cirillo L, Giannini G, Martinoni M, Zoli M, Tonon C, Lodi R, Conti A.   +19 more
europepmc   +1 more source

Cerebello-thalamic activity drives an abnormal motor network into dystonic tremor. [PDF]

Neuroimage Clin, 2022
Nieuwhof F, Toni I, Dirkx MF, Gallea C, Vidailhet M, Buijink AWG, van Rootselaar AF, van de Warrenburg BPC, Helmich RC.   +8 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Correction to: Motor network pre-habilitation by low-frequency repetitive transcranial magnetic stimulation. A proof-of-concept. [PDF]

Acta Neurochir (Wien)
Dor NB, Raffa G, Scibilia A, Espahbodinea S, Garcia C, La Torre D, Ziv G, Friso F, Granata F, Vinci S, Rustici A, Cardali SM, Garufi G, Cirillo L, Giannini G, Martinoni M, Zoli M, Tonon C, Lodi R, Conti A.   +19 more
europepmc   +1 more source

Preconditioning of the motor network with repetitive navigated transcranial magnetic stimulation (rnTMS) to improve oncological and functional outcome in brain tumor surgery: a study protocol for a randomized, sham-controlled, triple-blind clinical trial. [PDF]

Trials, 2023
Engelhardt M, Grittner U, Krieg S, Picht T.   +3 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Iron deposition is associated with motor and non-motor network breakdown in parkinsonism. [PDF]

Front Aging Neurosci
Leng F, Gao Y, Li F, Wei L, Sun Y, Liu F, Zhu Y, Qiu J, Wang Z, Zhang Y.   +9 more
europepmc   +1 more source

Task-State Cortical Motor Network Characteristics by Functional Near-Infrared Spectroscopy in Subacute Stroke Show Hemispheric Dominance. [PDF]

Front Aging Neurosci, 2022
Yuan Z, Xu W, Bao J, Gao H, Li W, Peng Y, Wang L, Zhao Y, Song S, Qiao J, Wang G.   +10 more
europepmc   +1 more source