Results 71 to 80 of about 5,650,462 (303)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Using Magnetoencephalography to Advance the Science of Parkinson Disease: A Systematic Review

Brain and Behavior
Purpose Magnetoencephalography (MEG) offers high temporal resolution and whole‐brain spatial coverage, making it a powerful tool to study brain networks.
Saar Kariv, Jeong Woo Choi, Mohsen Benam, Sahil Chilukuri, Amirreza Alijanpourotaghsara, Nader Pouratian   +5 more
doaj   +1 more source

Global efficiency of the motor network is decreased in Parkinson's disease in comparison with essential tremor and healthy controls

Brain and Behavior, 2021
Background Graph theory (GT) is a mathematical field that analyses complex networks that can be applied to neuroimaging to quantify brain's functional systems in Parkinson's disease (PD) and essential tremor (ET).
Natalia Pelizari Novaes, Joana Bisol Balardin, Fabiana Campos Hirata, Luciano Melo, Edson Amaro Jr., Egberto Reis Barbosa, João Ricardo Sato, Ellison Fernando Cardoso   +7 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Multipath-RTI: Millimeter-Wave Radio Based Device-Free Localization

IEEE Access
This paper presents a novel localization technique—Multipath-radio tomographic imaging (RTI)—based on millimeter-wave (mm-wave) radio systems, such as 5G mobile and WiGig LAN systems.
Togo Ikegami, Minseok Kim, Yuto Miyake, Hibiki Tsukada   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Motor network efficiency and disability in multiple sclerosis [PDF]

Neurology, 2015
To develop a composite MRI-based measure of motor network integrity, and determine if it explains disability better than conventional MRI measures in patients with multiple sclerosis (MS).Tract density imaging and constrained spherical deconvolution tractography were used to identify motor network connections in 22 controls. Fractional anisotropy (FA),
PARDINI, MATTEO, Yaldizli, Özgür, Sethi, Varun, Muhlert, Nils, Liu, Zheng, Samson, Rebecca S., Altmann, Daniel R., Ron, Maria A., Wheeler Kingshott, Claudia A. M., Miller, David H., Chard, Declan T.   +10 more
openaire   +8 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A new type of fault diagnosis method of asynchronous motor

Gong-kuang zidonghua, 2014
In view of problem of difficult parameters determination existed in fault diagnosis method of asynchronous motor based on RBF neural network, the paper proposed a fault diagnosis method of asynchronous motor based on RBF neural network optimized by ...
GOU Xijin, XU Jinxia, KONG Lili
doaj   +1 more source