Results 81 to 90 of about 305,411 (311)

Disrupted topological organization of the motor execution network in Wilson's disease

Frontiers in Neurology, 2022
ObjectiveThere are a number of symptoms associated with Wilson's disease (WD), including motor function damage. The neuropathological mechanisms underlying motor impairments in WD are, however, little understood. In this study, we explored changes in the
Long Zhu, Hongxi Yin, Yanxin Wang, Wenming Yang, Ting Dong, Lei Xu, Zhifeng Hou, Qiao Shi, Qi Shen, Zicheng Lin, Haixia Zhao, Yaqin Xu, Yanyan Chen, Jingjing Wu, Zheng Yu, Man Wen, Jiaying Huang   +16 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Neuronal and network activity in networks of cultured spinal motor neurons [PDF]

NeuroReport, 2009
This is the first report of multielectrode recordings from networks of cultured motor neurons. Neurons isolated from the ventral horns of spinal cords of E15 rats were cultured on MED64 probes. The majority of the neurons in the cultures are positive for neurofilament, choline acetyltransferase, and Hb9, characteristics of motor neurons.
Hong-Mei, Zhang, Natallia, Robinson, Ilsa, Gómez-Curet, Wenlan, Wang, Melissa A, Harrington   +4 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Sensory–motor networks involved in speech production and motor control: An fMRI study [PDF]

NeuroImage, 2015
Speaking is one of the most complex motor behaviors developed to facilitate human communication. The underlying neural mechanisms of speech involve sensory-motor interactions that incorporate feedback information for online monitoring and control of produced speech sounds.
Roozbeh Behroozmand, Rachel Shebek, Daniel R. Hansen, Hiroyuki Oya, Donald A. Robin, Matthew A. Howard III, Jeremy D. W. Greenlee   +6 more
openaire   +2 more sources

Exploiting SRv6 for Stateless and Per-Connection-Consistent Load Balancing

IEEE Access
This paper proposes a new load-balancing method that supports Per-Connection Consistency (PCC) by leveraging ECMP with standardized routing protocols for operational simplicity.
Ryo Nakamura, Kentaro Ebisawa, Hideaki Hayashi, Tatsuya Fujiwara, Tomoko Okuzawa   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Metamodulation of a spinal locomotor network by nitric oxide

, 2010
Flexibility in the output of spinal networks can be accomplished by the actions of neuromodulators; however, little is known about how the process of neuromodulation itself may be modulated.
Sillar, Keith Thomas, McLean, DL
core   +1 more source

Different brain circuits underlie motor and perceptual representations of temporal intervals [PDF]

, 2008
In everyday life, temporal information is used for both perception and action, but whether these two functions reflect the operation of similar or different neural circuits is unclear.
Walsh, V., Bueti, D., Rees, G., Chris Frith, Frith, C, Bueti, Domenica, Walsh, V, Vincent Walsh, Geraint Rees, Frith, C., Domenica Bueti   +10 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source