Results 281 to 290 of about 390,159 (364)

Covalent Binding of Dexamethasone to Polyimide Improves Biocompatibility of Neural Implantable Devices

Advanced Healthcare Materials, EarlyView.
The covalent binding of dexamethasone to the surface of polyimide represents the electrically inert part of implantable intraneural devices. This ensures a sustained release of the drug for 9 weeks. In vitro and in vivo tests confirm the reduction of the foreign body reactions and the improved biocompatibility of dexamethasone functionalized polyimide.
Giulia Turrin, Jose Crugeiras, Chiara Bisquoli, Davide Barboni, Martina Catani, Bruno Rodríguez‐Meana, Rita Boaretto, Michele Albicini, Stefano Caramori, Claudio Trapella, Thomas Stieglitz, Yara Baslan, Hanna Karlsson‐Fernberg, Fernanda L. Narvaez‐Chicaiza, Edoardo Marchini, Alberto Cavazzini, Ruben López‐Vales, Maria Asplund, Xavier Navarro, Stefano Carli   +19 more
wiley   +1 more source

Biohybrid motor neuron spheroid composed of graphene/HUVEC/neural cell for 3D biosensing system to evaluate drug of amyotrophic lateral sclerosis. [PDF]

Nano Converg
Shin M, Ha T, Lee S, Li C, Choi JH, Choi JW.   +5 more
europepmc   +1 more source

Transgenic and gene-targeting approaches to model disorders of motor neurons

, 1996
Philip C. Wong, David Borchelt, Michael K. Lee, Carlos A. Pardo, Sangram S. Sisodia, Don W. Cleveland, Vassilis E. Koliatsos, Donald L. Price   +7 more
openalex   +1 more source

Advanced Multipurpose Spectroscopic Nanobio‐Device for Concurrent Lab‐on‐a‐Chip Label‐Free Separation and Detection of Extracellular Vesicles as Key‐Biomarkers for Point‐of‐Care Cardiovascular Disease Diagnostics

Advanced Healthcare Materials, EarlyView.
AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan, Jonathan James Stanley Rickard, Mark Robert Thomas, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

Restoration of myogenesis in ALS-myocytes through miR-26a-5p-mediated Smad4 inhibition and its impact on motor neuron development. [PDF]

Mol Ther Nucleic Acids
Peggion C, Bonadio RS, Stella R, Scalabrin S, Pasetto L, Millino C, Camporeale L, Pacchioni B, Bonetto V, Bertoli A, Cagnin S, Massimino ML.   +11 more
europepmc   +1 more source

Nanomaterial‐Enhanced Biosensing: Mechanisms and Emerging Applications

Advanced Healthcare Materials, EarlyView.
Nanomaterial integration transforms biosensor capabilities through enhanced signal transduction, sensitivity, and selectivity. This review analyzes how nanoscale materials—from nanoparticles to nanosheets—leverage unique physicochemical properties to revolutionize electrochemical, optical, and electrical biosensing.
Younghak Cho, Yunyoung Choi, Yerim Jang, Hyejeong Seong   +3 more
wiley   +1 more source

Determinants and progression of stigma in amyotrophic lateral sclerosis/motor neuron disease. [PDF]

Amyotroph Lateral Scler Frontotemporal Degener
Young CA, Chaouch A, Mcdermott CJ, Al-Chalabi A, Chhetri SK, Bidder C, Edmonds E, Ellis C, Annadale J, Wilde L, Sharrack B, Malaspina A, Leach O, Mills R, Tennant A.   +14 more
europepmc   +1 more source

The neuron-specific kinesin superfamily protein KIF1A is a uniqye monomeric motor for anterograde axonal transport of synaptic vesicle precursors

, 1995
Yasushi Okada, Hiroto Yamazaki, Yoko Sekine‐Aizawa, Nobutaka Hirokawa   +3 more
openalex   +1 more source

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis, Vignesh Jayarajan, George M. Church, Roger D. Kamm, João Pedro de Magalhães, Emad Moeendarbary   +5 more
wiley   +1 more source

Electromyographic Study on the Inhibitory Effects of Local Cold- and Hot-Water Bathing of the Upper Limb on Finger Flexor α-Motor Neuron Activity. [PDF]

Cureus
Komatsu M, Nakajima M.
europepmc   +1 more source