Neural reactivations during sleep determine network credit assignment. [PDF]
, 2017 A fundamental goal of motor learning is to establish the neural patterns that produce a desired behavioral outcome. It remains unclear how and when the nervous system solves this 'credit assignment' problem.
Bodepudi, Anitha +4 more
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Agrin isoforms and their role in synaptogenesis [PDF]
, 1992 Agrin is thought to mediate the motor neuron-induced aggregation of synaptic proteins on the surface of muscle fibers at neuromuscular junctions. Recent experiments provide direct evidence in support of this hypothesis, reveal the nature of agrin ...
Escher, Gérard +6 more
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Motor neurons and the generation of spinal motor neuron diversity [PDF]
Frontiers in Cellular Neuroscience, 2014 Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS) controlling a variety of downstream targets. This function infers the existence of MN subtypes matching the identity of the targets they innervate. To illustrate the mechanism involved in the generation of cellular diversity and the acquisition of specific identity, this
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Neuronal Development: Sorting out Motor Neurons [PDF]
Current Biology, 2002 In the developing spinal cord, motor neurons become segregated into important functional units termed motor pools. Now it has been discovered that repertoires of cadherin surface molecules play key roles in motor pool sorting.
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Dissociation of structural and functional integrities of the motor system in amyotrophic lateral sclerosis and behavioral-variant frontotemporal dementia [PDF]
, 2016 Background and Purpose: This study investigated the structural and functional changes in the motor system in amyotrophic lateral sclerosis (ALS; n=25) and behavioral-variant fronto-temporal dementia (bvFTD; n=17) relative to healthy controls (n=37 ...
Bae, Jong Seok +9 more
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Amyotrophic Lateral Sclerosis [PDF]
, 2019 The word amyotrophic is derived from Greek, and means “without nourishment to muscles”, lateral means to the sides and sclerosis means hardened (“What is ALS?,” n.d.).
Georgetson, Anastasia M.
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Identification of pathways of degeneration and protection in motor neuron diseases [PDF]
, 2017 Motor neuron diseases preferentially affect specific neuronal populations with distinct clinical features even if disease-causing genes are expressed in many cell types. In spinal muscular atrophy (SMA), somatic motor neurons are selectively vulnerable
Nichterwitz, Susanne
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Cortically evoked motor responses in patients with Xp22.3-linked Kallmann's syndrome and in female gene carriers [PDF]
, 1992 Patients with Kallmann's syndrome show hypothalamic hypogonadism, hyposmia, and congenital mirror movements. As a correlate, a defect of gonadotropic neuron migration into the brain was recently detected. Considering abnormal outgrowth of neurons also as
Aizawa +33 more
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Identification of Alternative Transcription Start Sites that Generate Neuron-Specific nhsl1b Isoform that Regulates Neuron Migration [PDF]
, 2020 Identification of Alternative Transcription Start Sites that Generate Neuron-Specific nhsl1b Isoform that Regulates Neuron Migration Abanoub Bector, Depts. of Biology and Chemistry, with Dr. Sarah Golding, Dept.
Bector, Abanoub
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Diagnosing motor neurone disease [PDF]
BMJ, 1996 Advanced motor neurone disease is easily recognised. Progressively worsening dysphagia and dysarthria, and widespread wasting and weakness of the limbs with hyperactive reflexes in a corresponding wasted myotome in the absence of other neurological signs are unmistakable features.
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