Results 121 to 130 of about 247,506 (355)

Degenerative and regenerative mechanisms governing spinal cord injury

Neurobiology of Disease, 2004
Spinal cord injury (SCI) is a major cause of disability, and at present, there is no universally accepted treatment. The functional decline following SCI is contributed to both direct mechanical injury and secondary pathophysiological mechanisms that are
Christos Profyris, Surindar S Cheema, DaWei Zang, Michael F Azari, Kristy Boyle, Steven Petratos   +5 more
doaj  

Advances in nanotechnology-based strategies for the treatments of amyotrophic lateral sclerosis

Materials Today Bio, 2020
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a progressive neurodegenerative disease that affects both upper and lower motor neurons, which results in loss of muscle control and eventual paralysis [1].
G.Y. Wang, S.L. Rayner, R. Chung, B.Y. Shi, X.J. Liang   +4 more
doaj  

Dominantly Inherited Amyotrophic Lateral Sclerosis (Motor Neuron Disease) [PDF]

, 1977
The term amyotrophic lateral sclerosis was first introduced by Charcot to describe cases with mixed upper and lower motor neuron signs without sensory impairment. Later the syndromes of progressive bulbar palsy (PBP) and progressive muscular atrophy (PMA)
Myer, Edwin C., Nance, Walter E., Wilkins, Louise E., Winter, Robin M.   +3 more
core   +1 more source

Elevated cerebrospinal fluid vasopressin in motor neuron disease. [PDF]

, 1987
Jonathan R. Seckl, Stafford L. Lightman, R J Guiloff   +2 more
openalex   +1 more source

Cervical Spinal Cord Magnetization Transfer Ratio and Its Relationship With Clinical Outcomes in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The cervical spinal cord (cSC) is highly relevant to clinical dysfunction in multiple sclerosis (MS) but remains understudied using quantitative magnetic resonance imaging (MRI). We assessed magnetization transfer ratio (MTR), a semi‐quantitative MRI measure sensitive to MS‐related tissue microstructural changes, in the cSC and its ...
Lisa Eunyoung Lee, Julien Cohen‐Adad, Irene M. Vavasour, Melanie Guenette, Katherine Sawicka, Neda Rashidi‐Ranjbar, Nathan Churchill, Akash Chopra, Adelia Adelia, Pierre‐Louis Benveniste, Anthony Traboulsee, Nathalie Arbour, Fabrizio Giuliani, Larry D. Lynd, Scott B. Patten, Alexandre Prat, Alice Schabas, Penelope Smyth, Roger Tam, Yunyan Zhang, Simon J. Graham, Mojgan Hodaie, Anthony Feinstein, Shannon Kolind, Tom A. Schweizer, Jiwon Oh, CanProCo Study Group   +26 more
wiley   +1 more source

Cyclin F can alter the turnover of TDP-43

Neurobiology of Disease
Previously, we demonstrated that the SCFcyclin F complex directly mediates the poly-ubiquitylation of TDP-43, raising the question of whether cyclin F can be used to enhance the turnover of TDP-43.
Stephanie L. Rayner, Alison Hogan, Jennilee M. Davidson, Tyler Chapman, Flora Cheng, Luan Luu, Sharlynn Wu, Selina Zhang, Shu Yang, Ian Blair, Marco Morsch, Roger Chung, Albert Lee   +12 more
doaj  

Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Multiple sclerosis (MS) patients often experience a higher incidence of clinical conditions before diagnosis, suggesting a prodromal phase. However, their predictive value and temporal trajectories remain underexplored. We investigated these aspects using the large UK Biobank's population‐based cohort, which provided clinical ...
Andrea Nova, Teresa Fazia, Giovanni Di Caprio, Davide Gentilini, Luisa Bernardinelli, Roberto Bergamaschi   +5 more
wiley   +1 more source

Motor neuron disease. [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1994
K Ray-Chaudhuri, P N Leigh
openaire   +4 more sources

Precise temporal regulation of alternative splicing during neural development

Nature Communications, 2018
The precise timing of neurodevelopmental splicing switches and the underlying regulatory mechanisms remain poorly understood. This study identifies two major waves of developmental switches under the control of distinct combinations of RNA-binding ...
Sebastien M. Weyn-Vanhentenryck, Huijuan Feng, Dmytro Ustianenko, Rachel Duffié, Qinghong Yan, Martin Jacko, Jose C. Martinez, Marianne Goodwin, Xuegong Zhang, Ulrich Hengst, Stavros Lomvardas, Maurice S. Swanson, Chaolin Zhang   +12 more
doaj   +1 more source

Effects of Nicotine on Embryological Neural Development [PDF]

, 2007
1st Place in Denman Undergraduate Research ForumOver 1 million women, approximately 12-22% of the U.S. population, smoke while pregnant (Centers for Disease Control).
Subbarao, Tara
core