Results 111 to 120 of about 6,382,817 (308)

Spliceosome integrity is defective in the motor neuron diseases ALS and SMA

EMBO Molecular Medicine, 2013
Two motor neuron diseases, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), are caused by distinct genes involved in RNA metabolism, TDP‐43 and FUS/TLS, and SMN, respectively.
Hitomi Tsuiji, Yohei Iguchi, Asako Furuya, Ayane Kataoka, Hiroyuki Hatsuta, Naoki Atsuta, Fumiaki Tanaka, Yoshio Hashizume, Hiroyasu Akatsu, Shigeo Murayama, Gen Sobue, Koji Yamanaka   +11 more
doaj   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Plasma Neurofilament Heavy Chain Levels Correlate to Markers of Late Stage Disease Progression and Treatment Response in SOD1(G93A) Mice that Model ALS [PDF]

, 2012
Background: Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder characterised by progressive degeneration of motor neurons leading to death, typically within 3–5 years of symptom onset. The diagnosis of ALS is largely reliant
Greensmith Linda, Dick, J, Petzold, A, Linda Greensmith, Malaspina Andrea, Petzold Axel, Greensmith, L, Kalmar Bernadett, Kalmar, B, Dick James, Lu Ching-Hua, Lu, CH, Bernadett Kalmar, James Dick, Ching-Hua Lu, Lu, C-H, Andrea Malaspina, Malaspina, A, Axel Petzold   +18 more
core   +2 more sources

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Motor neuron disease associated with carcinoma

, 2017
Paraneoplastic complications are obscure and difficult to understand. The association of motor neuron disease and carcinoma may sometimes be more than coincidental, and 2 cases are described.
Fritz, V.U., Kaplan, C.L., Gritzman, M.C.D., Perkins, S   +3 more
core  

Focus on the role of D-serine and D-amino acid oxidase in Amyotrophic Lateral Sclerosis/ Motor Neuron Disease (ALS) [PDF]

, 2018
We have investigated a pathogenic mutation in D-amino acid oxidase (DAO), DAOR199W, associated with familial Amyotrophic Lateral Sclerosis (ALS) that impairs D-serine metabolism and causes protein aggregation, autophagy and cell death in motor neuron ...
Kondori, Nazanin Rahmani, Jacqueline P. Robbins, de Belleroche, JS, Dominic J. Wells, Ke Liu, Hildyard, John, Liu, Ke, Paul, Praveen, Wells, Dominic, Paul, P, Robbins, Jacqueline, Kondori, N R, Nazanin R. Kondori, Liu, K, Praveen Paul, John C. W. Hildyard, Robbins, J P, Jacqueline S. de Belleroche, Wells, D J, Hildyard, J C W, De Belleroche, J S   +20 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

The cost of mentalizing: executive contributions to social cognition performance in amyotrophic lateral sclerosis

Frontiers in Psychology
BackgroundMentalizing deficits are common in amyotrophic lateral sclerosis (ALS). Performance at high-level socio-cognitive tasks may be particularly vulnerable to integrity of basic cognitive processes.
Chiara Cerami, Chiara Cerami, Andrea Panzavolta, Veronica Faltracco, Eleonora Dalla Bella, Nilo Riva, Alessandra Telesca, Federica Ferrara, Alessandra Dodich, Christian Lunetta, Monica Consonni   +10 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Tofersen Treatment in

Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Objective: To evaluate the effectiveness of Tofersen in patients with superoxide dismutase 1 gene ( SOD1-ALS ) patients in France in a real-world setting, using disease progression within patient comparisons and with a historical cohort.
Daniells Erazo, MD, PhD, Adele Hesters, MD, Gaëlle Bruneteau, MD, PhD, Elisa De La Cruz, MD, Emilien Bernard, MD, Aude-Marie Grapperon, MD, Gwendal Le Masson, MD, PhD, Pascal Cintas, MD, Marie-Hélène Soriani, MD, Nathalie Guy, MD, Julien Cassereau, MD, PhD, Jean-Philippe Camdessanché, MD, PhD, Steeve Genestet, MD, PhD, Philippe Corcia, MD, PhD, Sophie Pittion, MD, Véronique Danel, MD, Mathilde Filliatre, MD, Ariane Choumert, MD, Agnes Jacquin-Piques, MD, François Salachas, MD, Florence Esselin, MD, Adrien Bohic, MD, Géraldine Lautrette, MD, Shahram Attarian, MD, PhD, Julie Catteau, PhD, Claire Guissart, MD, Marie-Claire Vincent, MD, Kevin Mouzat, MD, PhD, Marie Temple, MD, Patrick Vourc’h, MD, PhD, Philippe Couratier, MD, PhD   +30 more
doaj   +1 more source