Results 121 to 130 of about 164,738 (314)

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

An epidemiological study of motor neuron disease in Hong Kong

, 2005
Worldwide, the incidence of motor neuron disease (MND) has been increasing steadily over recent decades. We reported a follow-up epidemiology study of MND in this locality.
Cheng, TS, Mak, W, Fong, GCY, Cheung, RTF, Kwan, MC, Lam, K, Cheung, CM, Mok, KY, Cheng, WK, Tsoi, TH, Chim, CS, Ho, SL, Chan, KH, Tsang, KL   +13 more
core   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Language impairments in ALS/MND (Amyotrophic Lateral Sclerosis/Motor Neuron Disease)

, 2002
Paolo Bongioanni §, Giancarlo Buoiano C§, Marzia Magoni § § Neuroscience Dpt., Univ. Of Pisa, Italy c Corresponding author: Giancarlo Buoiano Via del Morello 8 Bargecchia I-55040 Corsanico (LU) email: giancarlo@neurolinguistics.0catch.com Language ...
Buoiano, Dr. Giancarlo, Magoni, Dr. Marzia, Bongioanni, Dr. Paolo   +2 more
core  

Cognitive and motor findings of patients with motor neuron disease.

, 2018
Cognitive and motor findings of patients with motor neuron disease.
William A. Stern (704087), Nicholas T. Olney (6029375), Roland G. Henry (580649), Nico Papinutto (580647), Eduardo Caverzasi (580646), Antje Bischof (6029378), Howard Rosen (6029381), Catherine Lomen-Hoerth (812360), Bruce L. Miller (297862)   +8 more
core   +1 more source

Genetic characterisation of ATXN2 in Australian amyotrophic lateral sclerosis

Brain Disorders
Large expansions of a trinucleotide repeat encoding a polyglutamine tract in ATXN2 are a known cause of spinocerebellar ataxia 2, and intermediate length expansions in this gene have been reported as a risk factor and phenotypic modifier for amyotrophic ...
Sharlynn S.L. Wu, Emily P. McCann, Sandrine Chan Moi Fat, Natalie Grima, Lyndal Henden, Liam G. Fearnley, Patrick Chiu, Kelly L. Williams, Dominic B. Rowe, Garth A. Nicholson, Matthew C. Kiernan, Ian P. Blair, Shu Yang, Jennifer A. Fifita   +13 more
doaj   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Dissecting the Molecular Mechanisms of Motor Neurone Disease in Yeast and Worms [PDF]

Superoxide dismutase 1 (SOD1) is an enzyme responsible for intracellular breakdown of toxic reactive oxygen species in prokaryotes and eukaryotes. Mutations in SOD1 are linked to the motor neurone disease Amyotrophic lateral sclerosis (ALS), with around ...
Peswani, Amber Rose
core  

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

White matter changes in reward circuits of amyotrophic lateral sclerosis: a fixel-based study of appetite loss

BMC Medicine
Background Non-motor symptoms such as appetite loss contribute to weight and fat mass reduction in people living with Amyotrophic Lateral Sclerosis (plwALS), both of which are strong prognostic factors in the disease.
Jeryn Chang, Harry Lipscombe, Jinglei Lv, Pamela A. McCombe, Robert D. Henderson, Shyuan T. Ngo, Frederik J. Steyn, Thomas B. Shaw   +7 more
doaj   +1 more source