Results 221 to 230 of about 151,768 (312)

Chaperone dysfunction in motor neuron disease: new insights from studies of the SMN complex. [PDF]

Genetics
Matera AG.
europepmc   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Mapping the Evidence for Measuring Energy Expenditure and Indicating Hypermetabolism in Motor Neuron Disease: A Scoping Review. [PDF]

Nutr Rev
Roscoe SA, Allen SP, McDermott CJ, Stavroulakis T.   +3 more
europepmc   +1 more source

Ultrasound‐Triggered Gelation for Restoring Biomechanical Properties of Degenerated Functional Spinal Units

Advanced Healthcare Materials, EarlyView.
This study introduces an innovative approach to treating intervertebral disc degeneration using ultrasound‐triggered in situ hydrogel formation. Proof‐of‐concept experiments using optimized biomaterial and ultrasound parameters demonstrate partial restoration of biomechanical function and successful integration into degenerated disc tissue, offering a ...
Veerle A. Brans, Anna P. Constantinou, Matthew J. Kibble, Valeria Nele, Daniel Reumann, Luca Bau, Sebastien J. P. Callens, James P. K. Armstrong, Nicolas Newell, Constantin C. Coussios, Molly M. Stevens, Michael D. Gray   +11 more
wiley   +1 more source

Identification of passive wrist-worn accelerometry outcomes for improved disease monitoring and trial design in motor neuron disease. [PDF]

EBioMedicine
Holdom CJ, Pilkar R, Guo CC, Eijk RPAV, Sethi N, Henderson RD, Ngo ST, Steyn FJ.   +7 more
europepmc   +1 more source

Ectopic Motor Unit Activity in Motor Neuron Disease

, 2015
Boudewijn T.H.M. Sleutjes
openalex   +1 more source

Controlling Intestinal Organoid Polarity using Synthetic Dynamic Hydrogels Decorated with Laminin‐Derived IKVAV Peptides

Advanced Healthcare Materials, EarlyView.
Design rules are presented to control intestinal organoid polarity in fully synthetic hydrogels. The laminin‐derived IKVAV sequence is crucial to obtain correct intestinal organoid polarity. Increasing hydrogel dynamics further supports the growth of correctly polarized intestinal organoids, while a bulk level of stiffness (G’ ≈ 0.7 kPa) is crucial to ...
Laura Rijns, Joost A. P. M. Wijnakker, Victor A. Veenbrink, Riccardo Bellan, Fenna W. B. Craenmehr, Simone I. S. Hendrikse, Johnick F. van Sprang, Wim de Lau, E. W. Meijer, Hans Clevers, Patricia Y. W. Dankers   +10 more
wiley   +1 more source

Determinants and progression of stigma in amyotrophic lateral sclerosis/motor neuron disease. [PDF]

Amyotroph Lateral Scler Frontotemporal Degener
Young CA, Chaouch A, Mcdermott CJ, Al-Chalabi A, Chhetri SK, Bidder C, Edmonds E, Ellis C, Annadale J, Wilde L, Sharrack B, Malaspina A, Leach O, Mills R, Tennant A.   +14 more
europepmc   +1 more source

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source

Human amyotrophic lateral sclerosis/motor neuron disease: The disease-associated microglial pathway is upregulated while APOE genotype governs risk and survival. [PDF]

Brain Pathol
Ashford BA, Simpson JE, Dawson C, Boche D, Cooper-Knock J, Heath PR, Fillingham D, Appleby-Mallinder C, Wei W, Dunning M, Highley JR.   +10 more
europepmc   +1 more source