Results 231 to 240 of about 247,506 (355)

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, EarlyView.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Impact of the COVID-19 pandemic on the mental and physical wellbeing of patients with motor neuron disease and other neuromuscular disease. [PDF]

Front Neurol
Mazumder S, Carroll AS, Timmins HC, Kiernan MC, Mahoney CJ.   +4 more
europepmc   +1 more source

Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum, Abhirami Thumsi, Kara Dunn, Lindsey Druschel, Sierra Chimene, David Flores Prieto, Amberlyn Simmons, Shivani Mantri, Arezoo Esrafili, Srivatsan J. Swaminathan, Mytreyi Trivedi, Shreya Anandan, Crystal Willingham, Alondra Davila, Sahil Inamdar, Joslyn L. Mangal, Abhirami P. Suresh, Niveda M. Kasthuri, Madan Mohan Chandra Sekhar Jaggarapu, Nicole Appel, Taravat Khodaei, Nathan D. Ng, Alison Sundem, Sanmoy Pathak, George Bjorklund, Jason Newbern, Jeffrey Capadona, Sarah E. Stabenfeldt, Abhinav P. Acharya   +28 more
wiley   +1 more source

Clinicopathological correlates in the frontotemporal lobar degeneration-motor neuron disease spectrum. [PDF]

Brain
Carbayo Á, Borrego-Écija S, Turon-Sans J, Cortés-Vicente E, Molina-Porcel L, Gascón-Bayarri J, Rubio MÁ, Povedano M, Gámez J, Sotoca J, Juntas-Morales R, Almendrote M, Marquié M, Sánchez-Valle R, Illán-Gala I, Dols-Icardo O, Rubio-Guerra S, Bernal S, Caballero-Ávila M, Vesperinas A, Gelpi E, Rojas-García R.   +21 more
europepmc   +1 more source

Epidemiology of equine motor neuron disease.

, 1994
Hussni O. Mohammed, J. F. Cummings, T. J. Divers, R. de la Rua‐Domenech, A de Lahunter   +4 more
openalex   +1 more source

Motor Neuron Disease Occurring in a Mutant Dynactin Mouse Model Is Characterized by Defects in Vesicular Trafficking [PDF]

, 2008
Fiona M. Laird, Mohamed H. Farah, Steven Ackerley, Ahmet Höke, Nicholas J. Maragakis, Jeffrey D. Rothstein, John H. Griffin, Donald L. Price, Lee J. Martin, Philip C. Wong   +9 more
openalex   +1 more source

Motor Neurone Disease [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1994
openaire   +2 more sources

A Targeted Redox‐Active Dual‐Action Pt(IV)‐Mn(II) Prodrug Displays Enhanced In Vivo Anticancer Activity

Advanced Healthcare Materials, EarlyView.
A new oxaliplatin‐based Pt(IV) prodrug bearing a Mn(II) superoxide dismutase mimic is synthesized and studied, in vitro and in vivo, in the context of colorectal cancer. Encapsulation of this prodrug in an easy‐to‐implement PEGylated micelle formulation demonstrated the highest in vivo anticancer activity among all the tested conditions, supporting the
Alvaro Lopez‐Sanchez, Henri Chédotal, Ram Pravin Kumar Muthuramalingam, Marine Thomas, Jia Ning Nicolette Yau, Priya Ranjan Sahoo, Clotilde Policar, Frédéric Batteux, Kadda Medjoubi, Andrea Somogyi, Giulia Adriani, Carole Nicco, Romain Coriat, Giorgia Pastorin, Hélène C. Bertrand   +14 more
wiley   +1 more source

A Case of Facial-Onset Sensory Motor Neuronopathy - A Rare Variant of Motor Neuron Disease. [PDF]

Ann Indian Acad Neurol
Kumar SP, Haritha S, Sowmini PR, Lakshmanan S, Velayutham SS, Jeyaraj KM, Kannan V, Saravanan RV, Mugundhan K.   +8 more
europepmc   +1 more source

Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition [PDF]

, 2008
Jan Hauke, Markus Rießland, Sebastian Lunke, Ilker Y. Eyüpoglu, Ingmar Blümcke, Assam El‐Osta, Brunhilde Wirth, Eric Hahnen   +7 more
openalex   +1 more source