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Motor Neuron Disease

Physical Medicine and Rehabilitation Clinics of North America, 2001
Motor neuron disease refers to a spectrum of disorders resulting from degeneration of the upper or lower motor neurons or both. Amyotrophic lateral sclerosis is the most common form of motor neuron disease, in which patients demonstrate evidence of both anterior horn cell (lower motor neuron) and corticospinal tract (upper motor neuron) dysfunction ...
Carlayne E. Jackson, Jeffrey Rosenfeld
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“A” motor neuron disease

Journal of the Neurological Sciences, 2014
Allgrove syndrome is a rare autosomal recessive disorder characterised by achalasia, alacrima, adrenal insufficiency, autonomic dysfunction and amyotrophy. The syndrome has been described in childhood and adult presentation, as in our case, is very rare.
Manoj Kumar Goyal   +4 more
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Motor neurone disease

2018
Motor neurone disease (MND) patients exhibit poor gait, balance, and postural control, all of which significantly increases their risk of falling. Falls are frequent in the MND population, and are associated with an increased burden of disease. The complex interplay of both motor and extramotor manifestations in this disease contributes to the ...
William Huynh   +4 more
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Neurons but Motor Neurons in Motor Neuron disease

Italian journal of anatomy and embryology, 2013
The occurrence of motor neuron death is the milestone of amyotrophic lateral sclerosis (ALS). Therefore, morphological analysis along decades focussed on motor neuron loss as the sole marker to score disease severity. Recently, non autonomous cell death took a prominent role to explain the need for additional cell types to induce motor neuron ...
Antonio Paparelli   +8 more
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Motor neuron disease

2018
Motor neuron disease (MND) is characterized by progressive muscular weakness due to simultaneous degeneration of lower and upper motor neurons (L/UMNs). Involvement of LMNs, arising from the anterior horns of the spinal cord and brainstem, leads to secondary wasting as a result of muscle denervation.
Gregory T. Carter, Nanette C. Joyce
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Motor neurone disease

Nursing Standard, 2016
Essential facts Motor neurone disease describes a group of related diseases, affecting the neurones in the brain and spinal cord. Progressive, incurable and life-limiting, MND is rare, with about 1,100 people developing it each year in the UK and up to 5,000 people affected at any one time.
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Motor Neuron Diseases

2013
Motor neuron diseases (MNDs) represent a group of neurological diseases characterized by progressive deterioration of the motor neurons in the brain, brain stem, and spinal cord, leading to muscle weakness and wasting. Genetic MND may be caused by mutations in genes that are widely expressed.
Quijano-Roy, S.   +4 more
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Astrocytes in Motor Neuron Diseases

2019
Motor neuron disorders are highly debilitating and mostly fatal conditions for which only limited therapeutic options are available. To overcome this limitation and develop more effective therapeutic strategies, it is critical to discover the pathogenic mechanisms that trigger and sustain motor neuron degeneration with the greatest accuracy and detail.
Valori, Chiara F.   +3 more
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Motor neurone disease

InnovAiT: Education and inspiration for general practice, 2020
Motor neurone disease describes a group of rare, fatal, neurodegenerative disorders. They are devastating conditions that cause the loss of upper and/or lower motor neurones, leading to a variety of progressive neurological symptoms that can develop over months to years.
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Autophagy in motor neuron diseases

2020
Motor neuron diseases (MNDs) are a wide group of neurodegenerative disorders characterized by the degeneration of a specific neuronal type located in the central nervous system, the motor neuron (MN). There are two main types of MNs, spinal and cortical MNs and depending on the type of MND, one or both types are affected.
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