Results 91 to 100 of about 555,245 (354)

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Non-viral gene therapy that targets motor neurons in vivo

Frontiers in Molecular Neuroscience, 2014
A major challenge in neurological gene therapy is safe delivery of transgenes to sufficient cell numbers from the circulation or periphery. This is particularly difficult for diseases involving spinal cord motor neurons such as amyotrophic lateral ...
Mary-Louise eRogers, Kevin Sean Smith, Dusan eMatusica, Matthew eFenech, Lee eHoffman, Robert Archer Rush, Nicolas Hans Voelcker   +6 more
doaj   +1 more source

Effects of manipulating slowpoke calcium-dependent potassium channel expression on rhythmic locomotor activity in Drosophila larvae [PDF]

, 2013
Rhythmic motor behaviors are generated by networks of neurons. The sequence and timing of muscle contractions depends on both synaptic connections between neurons and the neurons’ intrinsic properties.
Atkinson, Atkinson, Atkinson, Barclay, Benhassine, Brand, Brenner, Carre-Pierrat, Cattaert, Ceriani, Cooper, del Negro, Dietzl, Du, Elkins, Elkins, Enríquez~Denton, Faber, Feng, Fernández, Fox, Fujioka, Gho, Golic, Gorassini, Grillner, Grillner, Gu, Guan, Harris-Warrick, Harris-Warrick, Hart, Heckman, Hoang, Hoel, Holden-Dye, Hooper, Hounsgaard, Kiehn, Komatsu, Kwon, Lazic, Lee, Lee, Liu, MacLean, Manuel, Marder, Marder, McLarnon, Mendenhall, Meredith, Osterwalder, Peng, Ping, Pulver, Revill, Saito, Salkoff, Sausbier, Schaefer, Scheckel, Shao, Singh, Singh, Song, Sun, Ueda, Vacher, Wang, Wang, Warbington, Wicher, Womack, Wright   +74 more
core   +1 more source

Advances in motor neurone disease [PDF]

Journal of the Royal Society of Medicine, 2014
Summary Motor neurone disease (MND), the commonest clinical presentation of which is amyotrophic lateral sclerosis (ALS), is regarded as the most devastating of adult-onset neurodegenerative disorders. The last decade has seen major improvements in patient care, but also rapid scientific advances, so that rational therapies based on key pathogenic ...
Bäumer, D, Talbot, K, Turner, M
openaire   +2 more sources

Motor Band Sign in Motor Neuron Disease: A Marker for Upper Motor Neuron Involvement

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2022
ABSTRACT:Background and Objective:The prevalence and role of the motor band sign (MBS) remain unclear in motor neuron disease. We report the frequency of MBS in amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS), its correlation with clinical upper motor neuron (UMN) signs, and prognostic value in ALS.Methods:We conducted a ...
Hee Sahng Chung, Gerd Melkus, Pierre Bourque, Santanu Chakraborty   +3 more
openaire   +2 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases. [PDF]

PLoS Genetics, 2017
The term "motor neuron disease" encompasses a spectrum of disorders in which motor neurons are the primary pathological target. However, in both patients and animal models of these diseases, not all motor neurons are equally vulnerable, in that while ...
Rachel A Kline, Kevin A Kaifer, Erkan Y Osman, Francesco Carella, Ariana Tiberi, Jolill Ross, Giuseppa Pennetta, Christian L Lorson, Lyndsay M Murray   +8 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Optogenetic methods to stimulate gamma motor neuron axons ex vivo

Experimental Physiology
It is challenging to stimulate gamma motor neurons, which are important regulators of muscle spindle afferent function, without also recruiting alpha motor neurons.
Apoorva Karekal, Remie Mandawe, Cameron Chun, Sai Kiran Byri, Danitza Cheline, Serena Ortiz, Shawn Hochman, Katherine A. Wilkinson   +7 more
doaj   +1 more source

Identification of a rhythmic firing pattern in the enteric nervous system that generates rhythmic electrical activity in smooth muscle [PDF]

, 2018
The enteric nervous system (ENS) contains millions of neurons essential for organization of motor behavior of the intestine. It is well established that the large intestine requires ENS activity to drive propulsive motor behaviors.
Brookes, Simon J, Costa, Marcello, Dinning, Phil G, Hibberd, Timothy J, Hu, Hongzhen, Keating, Damien J, Sorensen, Julian, Spencer, Nick J, Travis, Lee, Wattchow, David A, Wiklendt, Lukasz   +10 more
core   +2 more sources