Results 91 to 100 of about 2,514,411 (397)

Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases. [PDF]

PLoS Genetics, 2017
The term "motor neuron disease" encompasses a spectrum of disorders in which motor neurons are the primary pathological target. However, in both patients and animal models of these diseases, not all motor neurons are equally vulnerable, in that while ...
Rachel A Kline, Kevin A Kaifer, Erkan Y Osman, Francesco Carella, Ariana Tiberi, Jolill Ross, Giuseppa Pennetta, Christian L Lorson, Lyndsay M Murray   +8 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Optogenetic methods to stimulate gamma motor neuron axons ex vivo

Experimental Physiology
It is challenging to stimulate gamma motor neurons, which are important regulators of muscle spindle afferent function, without also recruiting alpha motor neurons.
Apoorva Karekal, Remie Mandawe, Cameron Chun, Sai Kiran Byri, Danitza Cheline, Serena Ortiz, Shawn Hochman, Katherine A. Wilkinson   +7 more
doaj   +1 more source

Magnetic resonance microimaging of the spinal cord in the SOD1 mouse model of amyotrophic lateral sclerosis detects motor nerve root degeneration [PDF]

, 2011
Amyotrophic lateral sclerosis (ALS) is characterized by selective degeneration of motor neurons. Current imaging studies have concentrated on areas of the brain and spinal cord that contain mixed populations of sensory and motor neurons.
Ali, Armon, Bendszus, Bilgen, Bilgen, Blackwell, Budde, Budde, Budde, Charles Watson, Cheung, Ciobanu, da Rocha, Ellis, Friedman, Gary J. Cowin, Gonzalez-Lara, Goodin, Gurney, Hanyu, Huang, Johnson, Kim, Kim, Levene, Loy, Luigetti, Luis, Ma, Ma, Marti-Fabregas, Mascalchi, McCreary, Nishi, Nyoman D. Kurniawan, Petrik, Pirko, Rajabally, Ravits, Robyn H. Wallace, Rosset, Scheenstra, Schellenberg, Schwarz, Sharief, Sobue, Tim J. Butler, Tu, Ullmann, Ullmann, Underwood, Watson, Wisco, Young   +53 more
core   +1 more source

Transcriptional profiling of differentially vulnerable motor neurons at pre-symptomatic stage in the Smn2b/- mouse model of spinal muscular atrophy

Acta Neuropathologica Communications, 2015
The term motor neuron disease encompasses a spectrum of disorders in which motor neurons are the lost. Importantly, while some motor neurons are lost early in disease and others remain intact at disease end-stage.
L. Murray, A. Beauvais, Sabrina Gibeault, N. L. Courtney, Rashmi Kothary   +4 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Sensory neurons do not induce motor neuron loss in a human stem cell model of spinal muscular atrophy. [PDF]

PLoS ONE, 2014
Spinal muscular atrophy (SMA) is an autosomal recessive disorder leading to paralysis and early death due to reduced SMN protein. It is unclear why there is such a profound motor neuron loss, but recent evidence from fly and mouse studies indicate that ...
Andrew J Schwab, Allison D Ebert
doaj   +1 more source

2406 Clinical phenotypes and survival in patients with Motor Neuron Disease in the Waikato region, New Zealand [PDF]

, 2022
Grace E. Oh, Mary Demopoulos, Matthew Phillips   +2 more
openalex   +1 more source

Novel peripheral motor neurons in the posterior tentacles of the snail responsible for local tentacle movements [PDF]

, 2014
Three flexor muscles of the posterior tentacles of the snail Helix pomatia have recently been described. Here, we identify their local motor neurons by following the retrograde transport of neurobiotin injected into these muscles.
Hernádi, László, Kiss, Tibor, Krajcs, Nóra, Teyke, T.   +3 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source