Results 201 to 210 of about 2,514,411 (397)

Effectiveness and Safety of Nusinersen and Risdiplam in Spinal Muscular Atrophy: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinal Muscular Atrophy (SMA) is a rare genetic disorder marked by progressive muscle weakness and mobility loss. It has a profound physical, emotional and social impact on patients and caregivers, requiring comprehensive medical and supportive care.
Amin Mehrabian, Peter Auguste, Amy Grove, Anna Brown, Janette Parr, Mubarak Patel, Furqan Butt, Jeremiah Donoghue, Mehdi Yousefi, Jo Parsons   +9 more
wiley   +1 more source

Dignity Therapy for People with Motor Neuron Disease and Their Family Caregivers: A Feasibility Study

, 2014
Samar Aoun, Harvey Max Chochinov, Linda J. Kristjanson   +2 more
openalex   +1 more source

Somatosensory Stimulation (Acupuncture) Modulates Spinal and Supraspinal Motor Neuron Excitability

, 2023
Akira Nihonmatsu
openalex   +2 more sources

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Tryptophan 32 mediates SOD1 toxicity in a in vivo motor neuron model of ALS and is a promising target for small molecule therapeutics

, 2018
Michèle G. DuVal, Vijaya Kumar Hinge, Natalie Snyder, Richard Kanyo, Jenna Bratvold, Edward Pokrishevsky, Neil R. Cashman, N. S. Blinov, Andriy Kovalenko, W. Ted Allison   +9 more
openalex   +2 more sources

Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS

Proceedings of the National Academy of Sciences of the United States of America, 2016
Mélanie Lalancette–Hébert, Aarti Sharma, Alex K Lyashchenko, N. Shneider   +3 more
semanticscholar   +1 more source

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source

Metabolic costs and trade-offs of hypermetabolism in human motor neurons with ATP synthase deficiency. [PDF]

Commun Biol
Torregrosa-Muñumer R, Turkia J, Ermiş R, Kvist J, Harjuhaahto S, Pennonen J, Hietakangas V, Ylikallio E, Tyynismaa H.   +8 more
europepmc   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Characterization of optogenetically activated inhibitory inputs onto cholinergic motor neurons in the spinal dorsolateral nucleus. [PDF]

Physiol Rep
Kamijo TC, Karnup S, Matsuoka K, Kimura S, Miyazato M, Daugherty SL, Beckel JM, Yoshimura N.   +7 more
europepmc   +1 more source