Results 81 to 90 of about 552,175 (353)
Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse [PDF]
, 2016 Boundary cap cells are a transient, neural-crest-derived population found at the motor exit point and dorsal root entry zone of the embryonic spinal cord.
Andrew M Garrett +7 more
core +2 more sources
BMC Neuroscience, 2011 Background The primary cilium is a solitary organelle important in cellular signaling, that projects from the cell surface of most growth-arrested or post-mitotic cells including neurons in the central nervous system.
Turnbull John +2 more
doaj +1 more source
Cells, 2020 Understanding the cellular and molecular basis of selective vulnerability has been challenging, especially for motor neuron diseases. Developing drugs that improve the health of neurons that display selective vulnerability relies on in vivo cell-based ...
Baris Genc +3 more
doaj +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Spatio-Temporal Patterning in Primary Motor Cortex at Movement Onset [PDF]
, 2017 Voluntary movement initiation involves the engagement of large populations of motor cortical neurons around movement onset. Despite knowledge of the temporal dynamics that lead to movement, the spatial structure of these dynamics across the cortical ...
Best, Matthew D. +4 more
core +1 more source
Novel peripheral motor neurons in the posterior tentacles of the snail responsible for local tentacle movements [PDF]
, 2014 Three flexor muscles of the posterior tentacles of the snail Helix pomatia have recently been described. Here, we identify their local motor neurons by following the retrograde transport of neurobiotin injected into these muscles.
Hernádi, László +3 more
core +1 more source
Neurobiology of Disease, 2005 Amyotrophic lateral sclerosis (ALS) is characterized by a progressive loss of large motor neurons in the brain and spinal cord. Amyloid precursor protein (APP), the transmembrane precursor of β-amyloid (Aβ), accumulates in the anterior horn motor neurons
Noel Y. Calingasan +3 more
doaj +1 more source
Localization of Motor Neurons and Central Pattern Generators for Motor Patterns Underlying Feeding Behavior in Drosophila Larvae. [PDF]
PLoS ONE, 2015 Motor systems can be functionally organized into effector organs (muscles and glands), the motor neurons, central pattern generators (CPG) and higher control centers of the brain.
Sebastian Hückesfeld +4 more
doaj +1 more source
FEBS Letters, EarlyView.Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia +5 more
wiley +1 more source
Identification of a rhythmic firing pattern in the enteric nervous system that generates rhythmic electrical activity in smooth muscle [PDF]
, 2018 The enteric nervous system (ENS) contains millions of neurons essential for organization of motor behavior of the intestine. It is well established that the large intestine requires ENS activity to drive propulsive motor behaviors.
Brookes, Simon J +10 more
core +2 more sources