Results 101 to 110 of about 10,285,166 (306)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Stochastically modulated inter-pulse intervals to increase the efficiency of functional electrical stimulation cycling

Journal of Rehabilitation and Assistive Technologies Engineering, 2018
Introduction Functional electrical stimulation cycling has various health benefits, but the mechanical power output and efficiency are very low compared to volitional muscle activation.
EA Aksöz, MA Luder, M Laubacher, R Riener, SA Binder-Macleod, KJ Hunt   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Comparison of Induction and PM Synchronous motor drives for EV application including design examples [PDF]

, 2012
Three different motor drives for electric traction are compared, in terms of output power and efficiency at the same stack dimensions and inverter size. Induction motor (IM), surface-mounted permanent-magnet (PM) (SPM), and interior PM (IPM) synchronous ...
Pellegrino, Gian-Mario Luigi, Guglielmi, Paolo, Vagati, Alfredo, PELLEGRINO, GIAN - MARIO LUIGI, Boazzo, Barbara   +4 more
core   +1 more source

Anaerobic Contribution Determined in Swimming Distances: Relation with Performance

Frontiers in Physiology, 2017
Total anaerobic contribution (TAn) can be assessed by accumulated oxygen deficit, and through sum of glycolytic and phosphagen contribution which enable the evaluation of TAn without influences on mechanical parameters. However, little is known about the
Eduardo Z. Campos, Eduardo Z. Campos, Carlos A. Kalva-Filho, Ronaldo B. Gobbi, Ricardo A. Barbieri, Nayara P. Almeida, Marcelo Papoti, Marcelo Papoti, Marcelo Papoti   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Investigating The Influence Of Attentiveness On Motor Imagery Performance

, 2023
Although much research has focused on motor imagery, the mental rehearsal of movement, little has examined the influence cognitive deficits have on its performance.
Green, Darby
core  

Agreement in Body Fat Percentage Estimates Between Three Common Bioelectrical Impedance Analysis Devices and a Myography-Based Analyzer in Healthy Young Adults

Biophysica
Background: Body composition assessment is highly relevant in various fields, including health and performance. This study aimed to evaluate the agreement in body fat percentage (BF%) estimates between three bioelectrical impedance analysis (BIA) devices
Jorge A. Aburto-Corona, Bryan Montero-Herrera, Juan J. Calleja-Núñez, Eva I. Torres, Michelle Y. Moroyoqui, Roberto Espinoza-Gutiérrez   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Performance estimation of interior permanent-magnet brushless motors using the voltage-driven flux-MMF diagram [PDF]

, 2006
The flux-magnetomotive force (flux-MMF) diagram, or "energy conversion loop," is a powerful tool for computing the parameters of saturated interior permanent-magnet brushless motors, especially when the assumptions underlying classical dq theory are not ...
Cossar, C., Miller, T. J. E., Popescu, M., McGilp, M. I.   +3 more
core   +1 more source