Results 61 to 70 of about 315,194 (303)

Long-term progressive motor skill training enhances corticospinal excitability for the ipsilateral hemisphere and motor performance of the untrained hand [PDF]

, 2017
It is well established that unilateral motor practice can lead to increased performance in the opposite non-trained hand. Here, we test the hypothesis that progressively increasing task difficulty during long-term skill training with the dominant right ...
Bapi, Barsi, Berniker, Boutin, Buetefisch, Camus, Carroll, Carroll, Carroll, Carroll, Chase, Chen, Cramer, Criscimagna-Hemminger, Davare, Devanne, Dragert, Dragert, Farthing, Farthing, Farthing, Flanagan, Hikosaka, Hinder, Hinder, Hortobágyi, Imamizu, Jensen, Kovacs, Krakauer, Lange, Laszlo, Lee, Lei, Leukel, Lundbye-Jensen, Lundbye-Jensen, Lundbye-Jensen, Magnus, Magnus, Mier, Morishita, Nakahara, Oldfield, Panzer, Panzer, Papandreou, Parkin, Perez, Perez, Perez, Rand, Rand, Ruddy, Ruddy, Schulze, Soteropoulos, Taylor, Tazoe, Trempe, Trempe, Verstynen, Wang, Yoo   +63 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

The effect of dopamine D2-like receptor blockade on human motor performance and skill acquisition

Scientific Reports
Dopamine signalling supports motor skill learning in a variety of ways, including through an effect on cortical and striatal plasticity. One neuromodulator that has been consistently linked to motor skill learning is dopamine.
Eleanor M. Taylor, Dylan Curtin, Trevor T.-J. Chong, Mark A. Bellgrove, James P. Coxon   +4 more
doaj   +1 more source

Scaling the Equipment and Play Area in Children’s Sport to improve Motor Skill Acquisition: A Systematic Review [PDF]

, 2016
BACKGROUND: This review investigated the influence of scaling sports equipment and play area (e.g., field size) on children’s motor skill acquisition.
Buszard, Tim, Farrow, Damian, Masters, Reid, Reid, Machar   +3 more
core   +1 more source

Policy Learning for Motor Skills [PDF]

, 2008
Policy learning which allows autonomous robots to adapt to novel situations has been a long standing vision of robotics, artificial intelligence, and cognitive sciences. However, to date, learning techniques have yet to fulfill this promise as only few methods manage to scale into the high-dimensional domains of manipulator robotics, or even the new ...
Peters, J., Schaal, S.
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Differential vulnerability of different forms of skill learning in Parkinson’s disease [PDF]

, 2014
The striatal dopaminergic dysfunction in Parkinson’s disease (PD) has been associated with deficits in skill learning in a number of studies, but the results are inconclusive so far.
Demeter, Gyula, Kemény, Ferenc, Lukács, Ágnes, Racsmány, Mihály, Valálik, István   +4 more
core  

Circuit Changes in Motor Cortex During Motor Skill Learning

Neuroscience, 2018
Motor cortex is important for motor skill learning, particularly the dexterous skills necessary for our favorite sports and careers. We are especially interested in understanding how plasticity in motor cortex contributes to skill learning. Although human studies have been helpful in understanding the importance of motor cortex in learning skilled ...
Andrew E, Papale, Bryan M, Hooks
openaire   +3 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source